217721 | InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem

217721
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₈H₁₃N₃OS₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      217721-2MG
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          Glass bottle 2 mg
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          Description
          OverviewA cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki =2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. The solid form of this compound (Cat. No. 217699) is also available.
          Catalogue Number217721
          Brand Family Calbiochem®
          Synonyms5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one, 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone
          References
          ReferencesVassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.
          Product Information
          FormLiquid
          FormulationA 10 mM (2 mg/569 µL) solution of Cdk1 Inhibitor IV, RO-3306 (Cat. No. 217699) in DMSO.
          Hill FormulaC₁₈H₁₃N₃OS₂
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCdk1/B1 and Cdk1/A
          Primary Target K<sub>i</sub>35 nM and 110 nM for Cdk1/B1 and Cdk1/A,
          Secondary targetCdk2/E, PKCδ, and SGK
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          217721

          References

          Reference overview
          Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-December-2012 JSW
          Synonyms5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one, 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone
          DescriptionA cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki =2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. The solid form of this compound (Cat. No. 217699) is also available.
          FormLiquid
          FormulationA 10 mM (2 mg/569 µL) solution of Cdk1 Inhibitor IV, RO-3306 (Cat. No. 217699) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
          Toxicity Irritant
          ReferencesVassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.