218861 | InSolution™ Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem

218861
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₄Br₄O₂ 934358-00-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218861-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. No. 218697 and Cat. No. 218708) and DMAT (Cat. No. 218699 and Cat. No. 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC50 = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.
          Catalogue Number218861
          Brand Family Calbiochem®
          Synonyms(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid
          References
          ReferencesPagano, M.A., et al. 2006. Chembiochem,/i> 8, 129.
          Product Information
          CAS number934358-00-6
          FormLiquid
          FormulationA 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.
          Hill FormulaC₉H₄Br₄O₂
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCKII
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          218861

          References

          Reference overview
          Pagano, M.A., et al. 2006. Chembiochem,/i> 8, 129.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-September-2012 JSW
          Synonyms(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid
          DescriptionA cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. No. 218697 and Cat. No. 218708) and DMAT (Cat. No. 218699 and Cat. No. 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC50 = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.
          FormLiquid
          FormulationA 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number934358-00-6
          Structure formulaStructure formula
          Purity≥90% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesPagano, M.A., et al. 2006. Chembiochem,/i> 8, 129.