504744 | InSolution™ Aphidicolin - CAS 38966-21-1 - Calbiochem

504744
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₃₄O₄ 38966-21-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04744.0001
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          Glass bottle 1 mg
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          Description
          Catalogue Number504744
          Brand Family Calbiochem®
          References
          ReferencesBorner, M.M., et al. 1995. Cancer Res. 55, 2122.
          Poluha, W., et al. 1995. Oncogene 10, 185.
          Urbani, L., et al. 1995. Exp. Cell Res. 219, 159. Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311. Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909. Hubermann, J.A. 1981. Cell 23, 647.
          Product Information
          CAS number38966-21-1
          FormLiquid
          FormulationA 30 mM (1 mg/98 µL) sterile-filtered solution of Aphidicolin (Cat. No. 178273) in DMSO.
          Hill FormulaC₂₀H₃₄O₄
          Chemical formulaC₂₀H₃₄O₄
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetDNA polymerase α and δ
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 24/25

          Avoid contact with skin and eyes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Borner, M.M., et al. 1995. Cancer Res. 55, 2122.
          Poluha, W., et al. 1995. Oncogene 10, 185.
          Urbani, L., et al. 1995. Exp. Cell Res. 219, 159. Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311. Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909. Hubermann, J.A. 1981. Cell 23, 647.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-January-2014 JSW
          DescriptionA cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific, non-competitive and reversible inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine (Cat. No. 677181)-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
          FormLiquid
          FormulationA 30 mM (1 mg/98 µL) sterile-filtered solution of Aphidicolin (Cat. No. 178273) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number38966-21-1
          Chemical formulaC₂₀H₃₄O₄
          Structure formulaStructure formula
          Purity≥98% by TLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions.
          Toxicity Irritant
          ReferencesBorner, M.M., et al. 1995. Cancer Res. 55, 2122.
          Poluha, W., et al. 1995. Oncogene 10, 185.
          Urbani, L., et al. 1995. Exp. Cell Res. 219, 159. Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311. Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909. Hubermann, J.A. 1981. Cell 23, 647.