124017 InSolution™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - Calbiochem

124017
  
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₄H₂₉N₇O
      Description
      Catalogue Number124017
      Brand Family Calbiochem®
      References
      ReferencesBarnett, S.F., et al. 2005. Biochem. J. 385, 399.
      DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271.
      Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905.
      Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761.
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationA 10 mM (1 mg/181 µl) solution of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) in DMSO.
      Hill FormulaC₃₄H₂₉N₇O
      Chemical formulaC₃₄H₂₉N₇O
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      ApplicationInSolution Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a 10 mM solution in DMSO. A cell-permeable, reversible, selective inhibitor of Akt1 & Akt2 (IC50 = 58 nM & 210 nM).
      Biological Information
      Primary TargetAkt1, Akt2, Akt3
      Primary Target IC<sub>50</sub>58 nM, 210 nM, and 2.12 µM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays
      Purity≥95% by HPLC
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - Calbiochem Certificates of Analysis

      TitleLot Number
      124017

      References

      Reference overview
      Barnett, S.F., et al. 2005. Biochem. J. 385, 399.
      DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271.
      Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905.
      Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761.

      Brochure

      Title
      In Solution!" Product Flyer
      New Research Tools for Signal Transduction and Life Science Research
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-August-2011 RFH
      DescriptionA cell-permeable, potent, and selective inhibitor of Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 µM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50 µM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo.
      FormLiquid
      FormulationA 10 mM (1 mg/181 µl) solution of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Concentration Label Please refer to vial label for lot-specific concentration
      Chemical formulaC₃₄H₂₉N₇O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage ≤ -70°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Irritant
      ReferencesBarnett, S.F., et al. 2005. Biochem. J. 385, 399.
      DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271.
      Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905.
      Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761.