118502 | InSolution™ ATM Kinase Inhibitor

118502
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₁H₁₇NO₃S₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      118502-2MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
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          Will advise
          Contact Customer Service

          Glass bottle 2 mg
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          Description
          Catalogue Number118502
          Brand Family Calbiochem®
          References
          ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
          Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
          Hickson, I., et al. 2004. Cancer Res. 64, 9152.
          Product Information
          FormLiquid
          FormulationA 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118500) in DMSO.
          Hill FormulaC₂₁H₁₇NO₃S₂
          Chemical formulaC₂₁H₁₇NO₃S₂
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          118502

          References

          Reference overview
          Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
          Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
          Hickson, I., et al. 2004. Cancer Res. 64, 9152.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-November-2008 JSW
          DescriptionA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents.
          FormLiquid
          FormulationA 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118500) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₁H₁₇NO₃S₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
          Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
          Hickson, I., et al. 2004. Cancer Res. 64, 9152.