658411 InSolution™ AG490 - Calbiochem

658411
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₇H₁₄N₂O₃

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      658411-5MG
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      Stocked 
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          Plastic ampoule 5 mg
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          Description
          Catalogue Number658411
          Brand Family Calbiochem®
          SynonymsJAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
          References
          ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
          Eriksen, K.W., et al. 2001. Leukemia 15, 787.
          Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891.
          Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
          Meydan, N., et al. 1996. Nature 379, 645.
          Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
          Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
          Product Information
          FormLiquid
          FormulationA 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658401) in DMSO.
          Hill FormulaC₁₇H₁₄N₂O₃
          Chemical formulaC₁₇H₁₄N₂O₃
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Once opened, stock solution is stable for up to 6 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          InSolution™ AG490 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          InSolution™ AG490 - Calbiochem Certificates of Analysis

          TitleLot Number
          658411

          References

          Reference overview
          Jaleel, M., et al. 2004. Biochemistry 43, 8247.
          Eriksen, K.W., et al. 2001. Leukemia 15, 787.
          Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891.
          Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
          Meydan, N., et al. 1996. Nature 379, 645.
          Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
          Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-November-2008 JSW
          SynonymsJAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
          DescriptionPotent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Jak family tyrosine kinase inhibitor. Inhibition of Jak2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal haematopoiesis. Inhibits the constitutive activation of STAT-3 and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. Also reported to inhibit guanylyl cyclase.
          FormLiquid
          FormulationA 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658401) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₇H₁₄N₂O₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Once opened, stock solution is stable for up to 6 months at -70°C.
          Toxicity Irritant
          ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
          Eriksen, K.W., et al. 2001. Leukemia 15, 787.
          Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891.
          Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
          Meydan, N., et al. 1996. Nature 379, 645.
          Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
          Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.