508436 InSolution™ AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem

508436
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₁₀FNO₂S • HCl 30827-99-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08436.0001
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          Glass bottle 50 mg
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          Description
          Catalogue Number508436
          Brand Family Calbiochem®
          SynonymsAEBSF, HCl InSolution, 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl, 4-(2-Aminoethyl)benzene-1-sulfonylfluoride, HCl
          References
          ReferencesCitron, M., et al. 1996. Neuron 17, 171.
          Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
          Mintz, G.R. 1993. BioPharm. 6, 34.
          Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
          Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
          Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
          Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.
          Product Information
          CAS number30827-99-7
          FormLiquid
          FormulationA 50 mM (50 mg/4.17 ml) sterile-filtered solution of AEBSF, Hydrochloride (Cat. No. 101500) in H₂O.
          Hill FormulaC₈H₁₀FNO₂S • HCl
          Chemical formulaC₈H₁₀FNO₂S • HCl
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetserine proteases
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Protect from Light Protect from light
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 1 year at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Citron, M., et al. 1996. Neuron 17, 171.
          Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
          Mintz, G.R. 1993. BioPharm. 6, 34.
          Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
          Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
          Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
          Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-January-2014 JSW
          SynonymsAEBSF, HCl InSolution, 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl, 4-(2-Aminoethyl)benzene-1-sulfonylfluoride, HCl
          DescriptionSpecific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPUα) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications.
          FormLiquid
          FormulationA 50 mM (50 mg/4.17 ml) sterile-filtered solution of AEBSF, Hydrochloride (Cat. No. 101500) in H₂O.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number30827-99-7
          Chemical formulaC₈H₁₀FNO₂S • HCl
          Structure formulaStructure formula
          Purity≥97% by HPLC
          Storage ≤ -70°C
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 1 year at -20°C.
          Toxicity Standard Handling
          ReferencesCitron, M., et al. 1996. Neuron 17, 171.
          Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
          Mintz, G.R. 1993. BioPharm. 6, 34.
          Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
          Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
          Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
          Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.