189826 | InSolution™ 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem

189826
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₁₂N₄O₄ 2353-33-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      189826-10MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 10 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.
          Catalogue Number189826
          Brand Family Calbiochem®
          SynonymsDecitabine
          References
          ReferencesEggert, A., et al. 2001. Cancer Res. 61, 1314.
          Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
          Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
          Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
          Haaf, T. 1995. Pharmacol. Ther. 65, 19.
          Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.
          Product Information
          CAS number2353-33-5
          FormLiquid
          FormulationA 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO.
          Hill FormulaC₈H₁₂N₄O₄
          Chemical formulaC₈H₁₂N₄O₄
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥ 98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Regulatory Review
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          189826

          References

          Reference overview
          Eggert, A., et al. 2001. Cancer Res. 61, 1314.
          Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
          Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
          Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
          Haaf, T. 1995. Pharmacol. Ther. 65, 19.
          Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.

          Technical Info

          Title
          White Paper - The Message in the Marks: Deciphering Cancer Epigenetics (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-June-2012 JSW
          SynonymsDecitabine
          DescriptionA cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.
          FormLiquid
          FormulationA 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number2353-33-5
          Chemical formulaC₈H₁₂N₄O₄
          Structure formulaStructure formula
          Purity≥ 98% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Regulatory Review
          ReferencesEggert, A., et al. 2001. Cancer Res. 61, 1314.
          Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921.
          Zhu, W.G., et al. 2001. Cancer Res. 61, 1327.
          Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315.
          Haaf, T. 1995. Pharmacol. Ther. 65, 19.
          Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85.