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647926 | InSolution™ Trichostatin A, Streptomyces sp. - Calbiochem

647926
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₇H₂₂N₂O₃

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      647926-500UG
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      Stocked 
      Discontinued
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      Available
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          Glass bottle 500 μg
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          Description
          Catalogue Number647926
          Brand Family Calbiochem®
          Synonyms4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, HDAC Inhibitor IX, TSA
          References
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationA 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647925) in DMSO.
          Hill FormulaC₁₇H₂₂N₂O₃
          Chemical formulaC₁₇H₂₂N₂O₃
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary Targethistone deactylase
          Primary Target IC<sub>50</sub>73 nM inhibiting IL-2 gene expression in Jurkat cells
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          647926
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-September-2008 RFH
          Synonyms4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, HDAC Inhibitor IX, TSA
          DescriptionA potent and reversible inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-tranformed NIH 3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model.
          FormLiquid
          FormulationA 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647925) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₇H₂₂N₂O₃
          Structure formula
          Purity≥98% by HPLC
          Storage -20°C
          Protect from light
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Harmful