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573130 | InSolution™ STAT3 Inhibitor VI, S3I-201 - Calbiochem

573130
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₆H₁₅NO₇S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      573130-5MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.). The solid form of this compound (Cat. No. 573102) is also available.
          Catalogue Number573130
          Brand Family Calbiochem®
          References
          ReferencesLin, L., et al. 2009. Oncogene, 28, 961.
          Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.
          Product Information
          FormLiquid
          FormulationA 50 mM (5 mg/274 µl) solution of STAT3 Inhibitor VI, S3I-201 (Cat. No. 573102) in DMSO.
          Hill FormulaC₁₆H₁₅NO₇S
          Chemical formulaC₁₆H₁₅NO₇S
          Hygroscopic Hygroscopic
          Structure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          573130

          References

          Reference overview
          Lin, L., et al. 2009. Oncogene, 28, 961.
          Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.

          Technical Info

          Title
          JAK/STAT Signaling Research Focus
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-February-2012 RFH
          DescriptionA cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.).
          FormLiquid
          FormulationA 50 mM (5 mg/274 µl) solution of STAT3 Inhibitor VI, S3I-201 (Cat. No. 573102) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₆H₁₅NO₇S
          Structure formula
          Purity≥95% by HPLC
          Storage -20°C
          Protect from light
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesLin, L., et al. 2009. Oncogene, 28, 961.
          Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.