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500582 | InSolution™ Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem

500582
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₆H₅₆O₈ 16561-29-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.00582.0001
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      Available
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          Glass bottle 2 mg
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          Description
          OverviewMost commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin (Cat. No. 344270, Cat. No. 344282)-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.
          Catalogue Number500582
          Brand Family Calbiochem®
          Synonyms12-O-Tetradecanoyl-phorbol-13-acetate, PMA, TPA
          References
          ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
          Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
          Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
          Macfarlane, D.E., and O'Donnell, P.S. 1993. Leukemia 7, 1846.
          Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
          Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
          Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
          Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
          Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
          Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
          Perchellet, J. 1985. Carcinogenesis 6, 567.
          Nishizuka, Y. 1984. Science 255, 1365.
          Mastro, A. 1982. Lymphokines 6, 263.
          Product Information
          CAS number16561-29-8
          FormLiquid
          FormulationA 10 mM (2 mg/324 µL) solution of Phorbol-12-myristate-13-acetate (Cat. No. 524400) in DMSO.
          Hill FormulaC₃₆H₅₆O₈
          Chemical formulaC₃₆H₅₆O₈
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetPKC
          Secondary targetCa2+-ATPase
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Use only fresh DMSO for preparing further dilutions.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
          Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
          Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
          Macfarlane, D.E., and O'Donnell, P.S. 1993. Leukemia 7, 1846.
          Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
          Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
          Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
          Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
          Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
          Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
          Perchellet, J. 1985. Carcinogenesis 6, 567.
          Nishizuka, Y. 1984. Science 255, 1365.
          Mastro, A. 1982. Lymphokines 6, 263.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-March-2013 JSW
          Synonyms12-O-Tetradecanoyl-phorbol-13-acetate, PMA, TPA
          DescriptionMost commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin (Cat. No. 344270, Cat. No. 344282)-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.
          FormLiquid
          FormulationA 10 mM (2 mg/324 µL) solution of Phorbol-12-myristate-13-acetate (Cat. No. 524400) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number16561-29-8
          Chemical formulaC₃₆H₅₆O₈
          Structure formula
          Purity≥98% by HPLC
          Storage ≤ -70°C
          Protect from light
          Hygroscopic
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Use only fresh DMSO for preparing further dilutions.
          Toxicity Irritant
          ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
          Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
          Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
          Macfarlane, D.E., and O'Donnell, P.S. 1993. Leukemia 7, 1846.
          Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
          Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
          Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
          Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
          Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
          Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
          Perchellet, J. 1985. Carcinogenesis 6, 567.
          Nishizuka, Y. 1984. Science 255, 1365.
          Mastro, A. 1982. Lymphokines 6, 263.