A part of MilliporeSigma

438187 | InSolution™ Lovastatin, Sodium Salt - Calbiochem

438187
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₄H₃₇O₆ • Na

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      438187-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewCarboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as a reversible competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
          Catalogue Number438187
          Brand Family Calbiochem®
          References
          ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
          Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
          McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
          Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
          Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
          Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
          Product Information
          FormLiquid
          FormulationA 10 mM (5 mg/1.13 ml) solution of Lovastatin, Sodium Salt (Cat. No. 438186) in H₂O.
          Hill FormulaC₂₄H₃₇O₆ • Na
          Chemical formulaC₂₄H₃₇O₆ • Na
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetHMG-CoA reductase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 24/25

          Avoid contact with skin and eyes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Harmful
          Storage ≤ -70°C
          Protect from Light Protect from light
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          438187

          References

          Reference overview
          Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
          Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
          McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
          Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
          Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
          Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-January-2013 JSW
          DescriptionCarboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as a reversible competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
          FormLiquid
          FormulationA 10 mM (5 mg/1.13 ml) solution of Lovastatin, Sodium Salt (Cat. No. 438186) in H₂O.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₄H₃₇O₆ • Na
          Structure formula
          Purity≥95% by HPLC
          Storage ≤ -70°C
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
          Toxicity Harmful
          ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
          Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
          McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
          Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
          Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
          Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.