A part of MilliporeSigma

431050 | InSolution™ Leptomycin B, Streptomyces sp. - CAS 87081-35-4 - Calbiochem

431050
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₃H₄₈O₆ 87081-35-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      431050-5UG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Alu drum 5 μg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewAn antifungal antibiotic that acts as an inhibitor of nuclear export because of its ability to interact with and impair the function of the nuclear export factor CRM1. It is about twice as potent as Leptomycin A (Cat. No. 431051) in inhibiting nucleocytoplasmic translocation of Rev, blocks the Rev-dependent export of mRNA into cytoplasm, and suppresses HIV-1 replication in primary human monocytes (IC50 = 600 pM). In addition, LMB effectively induces the accumulation of p53 in the nucleus of normal fibroblasts as well as protects p53 from Mdm2-mediated ubiquitination and degradation.
          Caution! Product contains volatile liquid. Keep product cold at all times.
          Catalogue Number431050
          Brand Family Calbiochem®
          SynonymsLMB, Chromosome Region Maintenance 1 Protein Inhibitor I, CRM1 Inhibitor I, Exportin 1 Inhibitor I, XPO1 Inhibitor I
          References
          ReferencesKau, T.R., and Silver, P.A. 2003. Drug Discov. Today 8, 78.
          Menendez, S., et al. 2003. Br. J. Cancer 88, 636.
          Xirodimas, D.P., et al. 2001. Exp. Cell Res. 270, 66.
          Kudo, N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 9112.
          Lain, S., et al. 1999. Exp. Cell Res. 248, 457.
          Wolff, B., et al. 1997. Chem. Biol. 4, 139.
          Yoshida, M., et al. 1990. Exp. Cell Res. 187, 150.
          Komiyama, K., et al. 1985. J. Antibiot. 38, 427.
          Product Information
          CAS number87081-35-4
          ATP CompetitiveN
          FormLiquid
          FormulationSupplied at 20 µg/ml (5 µg in 250 µl) in absolute ethanol
          Hill FormulaC₃₃H₄₈O₆
          Chemical formulaC₃₃H₄₈O₆
          ReversibleN
          Structure formula Image
          Applications
          ApplicationInSolution™ Leptomycin B, Streptomyces sp., CAS 87081-35-4, is a 20 µg/ml solution in ethanol. An antifungal agent that blocks nuclear export by impairing the function of nuclear export factor CRM1.
          Biological Information
          Primary TargetHIV-1 replication in primary human monocytes
          Primary Target IC<sub>50</sub>600 pM in suppressing HIV-1 replication in primary human monocytes
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Flammable
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage ≤ -70°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-70°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          431050

          References

          Reference overview
          Kau, T.R., and Silver, P.A. 2003. Drug Discov. Today 8, 78.
          Menendez, S., et al. 2003. Br. J. Cancer 88, 636.
          Xirodimas, D.P., et al. 2001. Exp. Cell Res. 270, 66.
          Kudo, N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 9112.
          Lain, S., et al. 1999. Exp. Cell Res. 248, 457.
          Wolff, B., et al. 1997. Chem. Biol. 4, 139.
          Yoshida, M., et al. 1990. Exp. Cell Res. 187, 150.
          Komiyama, K., et al. 1985. J. Antibiot. 38, 427.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-September-2007 RFH
          SynonymsLMB, Chromosome Region Maintenance 1 Protein Inhibitor I, CRM1 Inhibitor I, Exportin 1 Inhibitor I, XPO1 Inhibitor I
          DescriptionAn unsaturated, branched-chain fatty acid with a terminal lactone ring that acts as a potent inhibitor of CRM-1-mediated (exportin-1) nuclear export. Exhibits antibiotic, anti-fungal, and anti-tumor properties and blocks the progression of the cell cycle at the G1 and G2 phases. Shown to inhibit nucleo-cytoplasmic translocation of Rev at nanomolar concentrations and block Rev-dependent export of mRNA into the cytoplasm. Also shown to suppress HIV-1 replication in primary human monocytes (IC50 = 600 pM). Effectively induces the accumulation of p53 in the nucleus of normal fibroblasts and protects p53 from Mdm2-mediated ubiquitination and degradation. Useful for studies involving nuclear localization and protein trafficking in eukaryotic cells.

          Caution! Product contains volatile liquid. Keep product cold at all times.
          FormLiquid
          FormulationSupplied at 20 µg/ml (5 µg in 250 µl) in absolute ethanol
          Intert gas (Yes/No) Packaged under inert gas
          CAS number87081-35-4
          Chemical formulaC₃₃H₄₈O₆
          Structure formula
          Purity≥95% by HPLC
          Storage ≤ -70°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-70°C).
          Toxicity Flammable
          ReferencesKau, T.R., and Silver, P.A. 2003. Drug Discov. Today 8, 78.
          Menendez, S., et al. 2003. Br. J. Cancer 88, 636.
          Xirodimas, D.P., et al. 2001. Exp. Cell Res. 270, 66.
          Kudo, N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 9112.
          Lain, S., et al. 1999. Exp. Cell Res. 248, 457.
          Wolff, B., et al. 1997. Chem. Biol. 4, 139.
          Yoshida, M., et al. 1990. Exp. Cell Res. 187, 150.
          Komiyama, K., et al. 1985. J. Antibiot. 38, 427.