A part of MilliporeSigma

420127 | InSolution™ Jasplakinolide, Jaspis johnstoni - Calbiochem

420127
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₆H₄₅BrN₄O₆

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420127-50UG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 50 μg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          Catalogue Number420127
          Brand Family Calbiochem®
          References
          ReferencesRosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
          Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
          Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
          Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
          Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationA 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420107) in DMSO.
          Hill FormulaC₃₆H₄₅BrN₄O₆
          Chemical formulaC₃₆H₄₅BrN₄O₆
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula Image
          Applications
          ApplicationInSolution™ Jasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a 1 mM solution of Jasplakinolide, Jaspis johnstoni in DMSO. Acts as a potent inducer of actin polymerization and stabilization.
          Biological Information
          Primary TargetF-actin
          Primary Target IC<sub>50</sub>Kd = 15 nM for actin binding
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420127

          References

          Reference overview
          Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
          Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
          Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
          Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
          Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.

          Citations

          Title
        • Markus Utech, et al. (2005) Mechanism of IFN-γ-Induced Endocytosis of Tight Junction Proteins: Mysoin II-Dependent Vacuolarization of the Apical Plasma Membrane. Molecular Biology of the Cell 16, 5040-5052.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-March-2008 JSW
          DescriptionA cell-permeable F-actin probe. This macrocyclic cyclodepsipeptide, isolated from the marine sponge Jaspis johnstoni, is a potent inducer of actin polymerization and stabilization in vitro. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. Also displays fungicidal, insecticidal, and anticancer properties.
          FormLiquid
          FormulationA 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420107) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₆H₄₅BrN₄O₆
          Structure formula
          Purity≥90% by HPLC
          Storage -20°C
          Protect from light
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Harmful
          ReferencesRosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
          Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
          Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
          Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
          Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
          Citation
        • Markus Utech, et al. (2005) Mechanism of IFN-γ-Induced Endocytosis of Tight Junction Proteins: Mysoin II-Dependent Vacuolarization of the Apical Plasma Membrane. Molecular Biology of the Cell 16, 5040-5052.