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407602 | InSolution™ Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem

407602
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₁N₅O₄ 509093-47-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407602-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src. The solid form of this compound (Cat. No. 407601) is also available.
          Catalogue Number407602
          Brand Family Calbiochem®
          SynonymsN-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, N-(1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide
          References
          ReferencesSrivastava, R., et al. 2012. Cancer Res. 72, In press.
          Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
          Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.
          Product Information
          CAS number509093-47-4
          FormLiquid
          FormulationA 25 mM (5 mg/506 µL) solution of Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor (Cat. No. 407601) in DMSO.
          Hill FormulaC₂₀H₂₁N₅O₄
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetIRAK-1/4
          Primary Target IC<sub>50</sub>300 nM and 200 nM for IRAK-1 and -4
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407602

          References

          Reference overview
          Srivastava, R., et al. 2012. Cancer Res. 72, In press.
          Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
          Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-December-2012 JSW
          SynonymsN-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, N-(1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide
          DescriptionA cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src. The solid form of this compound (Cat. No. 407601) is also available.
          FormLiquid
          FormulationA 25 mM (5 mg/506 µL) solution of Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor (Cat. No. 407601) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number509093-47-4
          Structure formula
          Purity≥98% by HPLC
          Storage ≤ -70°C
          Protect from light
          Hygroscopic
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
          Toxicity Irritant
          ReferencesSrivastava, R., et al. 2012. Cancer Res. 72, In press.
          Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
          Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.