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658548 | InSolution™ AG 1478 - CAS 175178-82-2 - Calbiochem

658548
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₄ClN₃O₂ 175178-82-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      658548-1MG
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      Available
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          Glass bottle 1 mg
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          Description
          Catalogue Number658548
          Brand Family Calbiochem®
          References
          ReferencesLevitski, A., and Gazit, A. 1995. Science 267, 1782.
          Fry, D.W., et al. 1994. Science 265, 1093.
          Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047.
          Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.
          Product Information
          CAS number175178-82-2
          ATP CompetitiveY
          DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
          FormClear to faint tan liquid
          FormulationA 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.
          Hill FormulaC₁₆H₁₄ClN₃O₂
          Chemical formulaC₁₆H₁₄ClN₃O₂
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetEpidermal growth factor receptor kinase
          Primary Target IC<sub>50</sub>3 nM against of epidermal growth factor receptor kinase
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          658548

          References

          Reference overview
          Levitski, A., and Gazit, A. 1995. Science 267, 1782.
          Fry, D.W., et al. 1994. Science 265, 1093.
          Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047.
          Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.

          Citations

          Title
        • Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,.
        • Ying-Hong Feng, et al. (2005) Unconventional Homologous Internalization of the Angiotensin II Type-1 Receptor Induced by G-Protein-Independent Signals. Hypertension 46, 419-423.
        • Diane Gesty-Palmer, et al. (2005) b-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. Journal of Biological Chemistry 280, 32157-32167.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-September-2008 RFH
          DescriptionHighly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC50 > 100 µM), the platelet-derived growth factor (PDGF) receptor (IC50 > 100 µM), and p210Bcr-Abl (IC50 >50 µM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.
          FormClear to faint tan liquid
          FormulationA 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number175178-82-2
          Chemical formulaC₁₆H₁₄ClN₃O₂
          Structure formula
          Purity≥98% by HPLC
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesLevitski, A., and Gazit, A. 1995. Science 267, 1782.
          Fry, D.W., et al. 1994. Science 265, 1093.
          Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047.
          Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.
          Citation
        • Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,.
        • Ying-Hong Feng, et al. (2005) Unconventional Homologous Internalization of the Angiotensin II Type-1 Receptor Induced by G-Protein-Independent Signals. Hypertension 46, 419-423.
        • Diane Gesty-Palmer, et al. (2005) b-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. Journal of Biological Chemistry 280, 32157-32167.