401250 Ilimaquinone - CAS 71678-03-0 - Calbiochem

401250
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₃₀O₄ 71678-03-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401250-100UG
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          Plastic ampoule 100 μg
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          Description
          OverviewA cell-permeable marine sponge metabolite with anti-microbial, anti-HIV, anti-inflammatory, and anti-mitotic properties. Induces a complete and reversible breakdown of Golgi membranes into smaller vesicular structures and causes depolymerization of microtubules. Inhibits cellular methylations through its interaction with S-adenosylhomocysteinase. Blocks the cytotoxicity of ricin and diphtheria toxin. Acts as an inhibitor of the RNase H activity of HIV-1.
          Catalogue Number401250
          Brand Family Calbiochem®
          Synonyms3-[(Decahydro-1β,2β,4aβ-trimethyl-5-methylene-1-napthyl)methyl]-2-hydroxy-5-methoxybenzoquinone, IQ
          References
          ReferencesRadeke, H.S., et al. 1999. Chem. Biol. 6, 639.
          Radeke, H.S., and Snapper, M.L. 1998. Bioorg. Med. Chem. 6, 1227.
          Jamora, C., et al. 1997. Cell 91, 617.
          Nambiar, M.P., and Wu, H.C. 1995. Exp. Cell Res. 219, 671.
          Loya, S., and Hizi, A. 1993. J. Biol. Chem. 268, 9323.
          Takizawa, P.A., et al. 1993. Cell 73, 1079.
          Veit, B., et al. 1993. J. Cell Biol. 122, 1197.
          Product Information
          CAS number71678-03-0
          ATP CompetitiveN
          FormRed solid
          Hill FormulaC₂₂H₃₀O₄
          Chemical formulaC₂₂H₃₀O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetInduces a complete and reversible breakdown of Golgi membranes into smaller vesicular structures and causes depolymerization of microtubules.
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Radeke, H.S., et al. 1999. Chem. Biol. 6, 639.
          Radeke, H.S., and Snapper, M.L. 1998. Bioorg. Med. Chem. 6, 1227.
          Jamora, C., et al. 1997. Cell 91, 617.
          Nambiar, M.P., and Wu, H.C. 1995. Exp. Cell Res. 219, 671.
          Loya, S., and Hizi, A. 1993. J. Biol. Chem. 268, 9323.
          Takizawa, P.A., et al. 1993. Cell 73, 1079.
          Veit, B., et al. 1993. J. Cell Biol. 122, 1197.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-July-2008 RFH
          Synonyms3-[(Decahydro-1β,2β,4aβ-trimethyl-5-methylene-1-napthyl)methyl]-2-hydroxy-5-methoxybenzoquinone, IQ
          DescriptionA cell-permeable marine sponge metabolite that induces complete and reversible breakdown of Golgi membranes into smaller vesicular structures, possibly through the activation of heterotrimeric G-proteins. Blocks protein transport at the cis-Golgi and depolymerizes microtubules. Also possesses anti-HIV activity and the ability to inhibit the cytotoxicity of ricin and diphtheria toxin.
          FormRed solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number71678-03-0
          Chemical formulaC₂₂H₃₀O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
          Toxicity Standard Handling
          ReferencesRadeke, H.S., et al. 1999. Chem. Biol. 6, 639.
          Radeke, H.S., and Snapper, M.L. 1998. Bioorg. Med. Chem. 6, 1227.
          Jamora, C., et al. 1997. Cell 91, 617.
          Nambiar, M.P., and Wu, H.C. 1995. Exp. Cell Res. 219, 671.
          Loya, S., and Hizi, A. 1993. J. Biol. Chem. 268, 9323.
          Takizawa, P.A., et al. 1993. Cell 73, 1079.
          Veit, B., et al. 1993. J. Cell Biol. 122, 1197.