420326 | IRTK Activator III, DDN - Calbiochem

420326
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄H₈Cl₂O₆

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420326-25MG
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          Glass bottle 25 mg
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          Description
          OverviewAn orally bioavilable diacetyloxy-naphthoquinone compound that directly targets insulin receptor tyrosine kinase (IRTK) domain and specifically increases IR kinase activity with no effect on IGF-1R and EGFR. Shown to rapidly phosphorylate IR (Tyr1146 and Tyr1158/1162/1163) and IRS-1 and selectively activate insulin signaling Akt (Thr473) and ERK pathways in CHO-IGF-IR cells at 5 µM. Sensitizes insulin action, enhances glucose uptake in differentiated 3T3-L1 adipocytes and decreases blood glucose levels in both normal and diabetic C57BL/6J mice (20 mg/kg, p.o.).
          Catalogue Number420326
          Brand Family Calbiochem®
          Synonyms5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquinone
          References
          ReferencesHe, K., et al. 2011. J. Biol. Chem. 286, 37379.
          Product Information
          FormPale yellow-green powder
          Hill FormulaC₁₄H₈Cl₂O₆
          Chemical formulaC₁₄H₈Cl₂O₆
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420326

          References

          Reference overview
          He, K., et al. 2011. J. Biol. Chem. 286, 37379.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-August-2012 JSW
          Synonyms5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquinone
          DescriptionAn orally bioavilable diacetyloxy-naphthoquinone compound that directly targets insulin receptor tyrosine kinase (IRTK) domain and specifically increases IR kinase activity with no effect on IGF-1R and EGFR. Shown to rapidly phosphorylate IR (Tyr1146 and Tyr1158/1162/1163) and IRS-1 and selectively activate insulin signaling Akt (Thr473) and ERK pathways in CHO-IGF-IR cells at 5 µM. Sensitizes insulin action, enhances glucose uptake in differentiated 3T3-L1 adipocytes and decreases blood glucose levels in both normal and diabetic C57BL/6J mice (20 mg/kg, p.o.).
          FormPale yellow-green powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₄H₈Cl₂O₆
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesHe, K., et al. 2011. J. Biol. Chem. 286, 37379.