A part of MilliporeSigma

14-645M | IRR Protein, active, 250 µg

250 µg  Also available in 10 μg size (cat#14-645) and in bulk (cat#14-645-K).
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited AvailabilityLimited Availability
Limited Quantities Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service


      Contact Customer Service

      Click To Print This Page


      Replacement Information
      Catalogue Number14-645M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionIRR Protein, active, 250 µg
      OverviewN-terminal 6His-tagged, recombinant, human IRR, amino acids 944-1266.
      Product Information
      ApplicationActive, N-terminal 6His-tagged, recombinant, human IRR, amino acids 944-1266. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman IRR, amino acids 944-1266 expressed by baculovirus in Sf21 cells.
      Entrez Gene Number
      Gene Symbol
      • INSRR
      • IRR
      Protein TargetIRR
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P14616 # This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
      SIZE: 1297 amino acids; 143720 Da
      SUBUNIT: Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P14616 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 4 fibronectin type-III domains. & Contains 1 protein kinase domain.
      Molecular Weight37.9kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of MBP (13-104).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-645) and in bulk (cat#14-645-K).
      Transport Information
      Supplemental Information


      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-645 IRR Protein, active, 10 µg Show Pricing & Availability

      Product Families


      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases