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14-645 | IRR Protein, active, 10 µg

14-645
10 µg  
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      Overview

      Replacement Information
      Description
      Catalogue Number14-645
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionIRR Protein, active, 10 µg
      OverviewN-terminal 6His-tagged, recombinant, human IRR, amino acids 944-1266.
      References
      Product Information
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant, human IRR, amino acids 944-1266. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman IRR, amino acids 944-1266 expressed by baculovirus in Sf21 cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Gene Symbol
      • INSRR
      • IRR
      Protein TargetIRR
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P14616 # This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
      SIZE: 1297 amino acids; 143720 Da
      SUBUNIT: Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P14616 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 4 fibronectin type-III domains. & Contains 1 protein kinase domain.
      Molecular Weight37.9kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of MBP (13-104).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      IRR, active - 1623155 1623155
      IRR, active - 1624023 1624023

      References

      Reference overviewPub Med ID
      Comparative analysis of the signaling capabilities of the insulin receptor-related receptor
      Klammt, Jurgen, et al
      Biochem Biophys Res Commun, 327:557-64 (2005) 2005

      15629149 15629149
      Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas
      Weber, Axel, et al
      Clin Cancer Res, 9:5683-92 (2003) 2003

      14654552 14654552
      Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor.
      Hänze, J, et al.
      Horm. Metab. Res., 31: 77-9 (1999) 1999

      Show Abstract
      10226785 10226785
      Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin.
      Elmlinger, M W, et al.
      Regul. Pept., 84: 37-42 (1999) 1999

      Show Abstract
      10535406 10535406
      Primary structure of a putative receptor for a ligand of the insulin family.
      Shier, P and Watt, V M
      J. Biol. Chem., 264: 14605-8 (1989) 1989

      Show Abstract
      2768234 2768234

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      Product Families

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases