531399 IRE1 Inhibitor IV, A-106

531399
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₁H₈O₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.31399.0001
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          Glass bottle 25 mg
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          Description
          OverviewA cell permeable naphthaldehyde based compound that specifically targets the RNAse domain of IRE-1 (ERN1) and blocks the activation of X-box binding protein 1 (XBP-1). Shown to be equipotent to its parent compound, STF-083010. Blocks IRE-1 RNase activity via the formation of a stable Schiff base with K907 in the RNase domain of IRE-1, which prevents splicing of XBP-1mRNA. Downregulation of XBP-1 in Em-TCL1 CLL cells leads to apoptosis (~50 to 100 µM). Blocks the proliferation and survival of patient-derived pre-B ALL cells (10 to 50 thousand cells) in sub-lethally irradiated NOD/SCID mice in a dose-dependent manner.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531399
          Brand Family Calbiochem®
          SynonymsERN1 Inhibitor, A106
          References
          ReferencesKriss, C., et al. 2012. Blood. 120, 1027. Masouleh, B. K., et al. 2014. PNAS. 111, in press.
          Product Information
          FormYellowish-white powder
          Hill FormulaC₁₁H₈O₂
          Chemical formulaC₁₁H₈O₂
          Applications
          Biological Information
          Primary TargetIRE1
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications