412510 IRE1 Inhibitor I, STF-083010 - Calbiochem

412510
  
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₅H₁₁NO₃S₂
      Description
      OverviewA cell-permeable salicylidene compound that is shown to directly target Ireα1 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER stress-initiated endonuclease activity of Ire1 and blocks XPB1 mRNA splicing in MM cells at 60 µM and XBP1 activity in transgenic XBP1-luc mice (bortezomib 1mg/kg and 60 mg/kg of STF-083010, i.p.). Displays preferential cytotoxicity towards CD138+ cells over B, T and NK cells and antitumor properties.
      Catalogue Number412510
      Brand Family Calbiochem®
      SynonymsER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010, N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide
      References
      ReferencesLerner, A.G., et al. 2012 Cell Metabolism 16, 250.
      Papandreou, I., et al. 2010. Blood 117, )1311.
      Product Information
      FormYellow powder
      Hill FormulaC₁₅H₁₁NO₃S₂
      Chemical formulaC₁₅H₁₁NO₃S₂
      Structure formula ImageStructure formula Image
      Applications
      ApplicationIRE1 Inhibitor I, STF-083010, CAS 307543-71-1, is a cell-permeable compound that directly targets Ireα1 and disrupt Ire1-XBP1 unfolded protein response pathway in RPMI8226 multiple myeloma cells.
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      IRE1 Inhibitor I, STF-083010 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      IRE1 Inhibitor I, STF-083010 - Calbiochem Certificates of Analysis

      TitleLot Number
      412510

      References

      Reference overview
      Lerner, A.G., et al. 2012 Cell Metabolism 16, 250.
      Papandreou, I., et al. 2010. Blood 117, )1311.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-April-2012 JSW
      SynonymsER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010, N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide
      DescriptionA cell-permeable salicylidene compound that is shown to directly target Ireα1 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER stress-initiated endonuclease activity of Ire1 and blocks XPB1 mRNA splicing in MM cells at 60 µM and XBP1 activity in transgenic XBP1-luc mice (bortezomib 1mg/kg and 60 mg/kg of STF-083010, i.p.). Displays preferential cytotoxicity towards CD138+ cells over B, T and NK cells and antitumor properties.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅H₁₁NO₃S₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml; clear, yellow solution)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Regulatory Review
      ReferencesLerner, A.G., et al. 2012 Cell Metabolism 16, 250.
      Papandreou, I., et al. 2010. Blood 117, )1311.