412510 IRE1 Inhibitor I, STF-083010 - Calbiochem

412510
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₅H₁₁NO₃S₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      412510-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable salicylidene compound that is shown to directly target Ireα1 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER stress-initiated endonuclease activity of Ire1 and blocks XPB1 mRNA splicing in MM cells at 60 µM and XBP1 activity in transgenic XBP1-luc mice (bortezomib 1mg/kg and 60 mg/kg of STF-083010, i.p.). Displays preferential cytotoxicity towards CD138+ cells over B, T and NK cells and antitumor properties.
          Catalogue Number412510
          Brand Family Calbiochem®
          SynonymsER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide, N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide
          References
          ReferencesLerner, A.G., et al. 2012 Cell Metabolism 16, 250.
          Papandreou, I., et al. 2010. Blood 117, )1311.
          Product Information
          FormYellow powder
          Hill FormulaC₁₅H₁₁NO₃S₂
          Chemical formulaC₁₅H₁₁NO₃S₂
          Structure formula ImageStructure formula Image
          Applications
          ApplicationIRE1 Inhibitor I, STF-083010, CAS 307543-71-1, is a cell-permeable compound that directly targets Ireα1 and disrupt Ire1-XBP1 unfolded protein response pathway in RPMI8226 multiple myeloma cells.
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Regulatory Review
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          412510

          References

          Reference overview
          Lerner, A.G., et al. 2012 Cell Metabolism 16, 250.
          Papandreou, I., et al. 2010. Blood 117, )1311.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-April-2012 JSW
          SynonymsER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide, N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide
          DescriptionA cell-permeable salicylidene compound that is shown to directly target Ireα1 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER stress-initiated endonuclease activity of Ire1 and blocks XPB1 mRNA splicing in MM cells at 60 µM and XBP1 activity in transgenic XBP1-luc mice (bortezomib 1mg/kg and 60 mg/kg of STF-083010, i.p.). Displays preferential cytotoxicity towards CD138+ cells over B, T and NK cells and antitumor properties.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₅H₁₁NO₃S₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml; clear, yellow solution)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Toxicity Regulatory Review
          ReferencesLerner, A.G., et al. 2012 Cell Metabolism 16, 250.
          Papandreou, I., et al. 2010. Blood 117, )1311.