504361 | INCB 3284 Dimesylate - CAS 887401-93-6 - Calbiochem

504361
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₃₁F₃N₄O₄•2CH₄O₃ 887401-93-6

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04361.0001
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          Glass bottle 5 mg
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          Description
          OverviewA potent and highly selective human CCR2 (hCCR2) antagonist (IC50 = 3.7 nM, 4.7 nM, and 84 nM for monocyte chemoattractant protein-1 binding to hCCR2, chemotaxis activity, inhibition of the hERG potassium current, respectively).
          Catalogue Number504361
          Brand Family Calbiochem®
          Synonyms N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate, INCB 3284, INCB3284
          References
          ReferencesXia, M., et al. 2009. Expert Opinion on Therapeutic Patents. 19, 295.
          Xue, C., et al. 2011. ACS Med. Chem. Lett. 2, 450.
          Product Information
          CAS number887401-93-6
          FormOff-white solid
          Hill FormulaC₂₆H₃₁F₃N₄O₄•2CH₄O₃
          Chemical formulaC₂₆H₃₁F₃N₄O₄•2CH₄O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targethuman CCR2 (hCCR2)
          Primary Target IC<sub>50</sub>3.7 nM, 4.7 nM, and 84 nM for different assays.
          Purity≥98% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Xia, M., et al. 2009. Expert Opinion on Therapeutic Patents. 19, 295.
          Xue, C., et al. 2011. ACS Med. Chem. Lett. 2, 450.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-July-2013 JSW
          Synonyms N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate, INCB 3284, INCB3284
          DescriptionA potent and highly selective human CCR2 (hCCR2) antagonist (IC50 = 3.7 nM, 4.7 nM, and 84 nM for monocyte chemoattractant protein-1 binding to hCCR2, chemotaxis activity, inhibition of the hERG potassium current, respectively).
          FormOff-white solid
          CAS number887401-93-6
          Chemical formulaC₂₆H₃₁F₃N₄O₄•2CH₄O₃
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (12 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesXia, M., et al. 2009. Expert Opinion on Therapeutic Patents. 19, 295.
          Xue, C., et al. 2011. ACS Med. Chem. Lett. 2, 450.