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401251 | IM-412 - Calbiochem

401251
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₆H₁₄ClN₅O₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401251-10MG
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      Stocked 
      Discontinued
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      Available
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          Glass bottle 10 mg
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          Description
          OverviewA cell permeable imidazoxanthine shown to decrease TGF-β stimulated reporter activity in a dose-dependent manner in HEK293 reporter cells, with an IC50 of 4.1 µM without cell cytotoxicity. Inhibits TGF-β receptor I (TβRI) and TGF-β receptor II (TβRII) expression and its downstream Smad2 and Smad3 phosphorylation as well as JNK and ERK activity. In addition, it elicits TGF-β-induced fibroblast differentiation with attenuated expression of several fibrotic markers such as α-SMA and fibronectin, and suppresses collagen accumulation in CCD-18Lu human normal lung fibroblasts.
          Catalogue Number401251
          Brand Family Calbiochem®
          Synonyms3-(2-chlorobenzyl)-1,7-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, TGF beta Inhibitor, IM-412
          References
          ReferencesPark, S., et al. 2010. Biochem. Biophy. Res. Comm. 399, 268.
          Product Information
          FormOff-white solid
          Hill FormulaC₁₆H₁₄ClN₅O₂
          Chemical formulaC₁₆H₁₄ClN₅O₂
          Structure formula Image
          Applications
          Biological Information
          Purity≥90% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          401251

          References

          Reference overview
          Park, S., et al. 2010. Biochem. Biophy. Res. Comm. 399, 268.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-February-2011 RFH
          Synonyms3-(2-chlorobenzyl)-1,7-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, TGF beta Inhibitor, IM-412
          DescriptionA cell permeable imidazoxanthine shown to decrease TGF-β stimulated reporter activity in a dose-dependent manner in HEK293 reporter cells, with an IC50 of 4.1 µM without cell cytotoxicity. Inhibits TGF-β receptor I (TβRI) and TGF-β receptor II (TβRII) expression and its downstream Smad2 and Smad3 phosphorylation as well as JNK and ERK activity. In addition, it elicits TGF-β-induced fibroblast differentiation with attenuated expression of several fibrotic markers such as α-SMA and fibronectin, and suppresses collagen accumulation in CCD-18Lu human normal lung fibroblasts.
          FormOff-white solid
          Chemical formulaC₁₆H₁₄ClN₅O₂
          Structure formula
          Purity≥90% by HPLC
          SolubilityDMSO (3 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesPark, S., et al. 2010. Biochem. Biophy. Res. Comm. 399, 268.