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401486 | IKK Inhibitor VII - CAS 873225-46-8 - Calbiochem

401486
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₂₉N₅OS 873225-46-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401486-1MG
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          Glass bottle 1 mg
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          Description
          OverviewA cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats. Also available as a 10 mM solution in DMSO (Cat. No. 505378).
          Catalogue Number401486
          Brand Family Calbiochem®
          SynonymsIKK 16
          References
          ReferencesWaelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108.
          Product Information
          CAS number873225-46-8
          ATP CompetitiveY
          FormPale yellow solid
          Hill FormulaC₂₈H₂₉N₅OS
          Chemical formulaC₂₈H₂₉N₅OS
          ReversibleN
          Structure formula Image
          Applications
          ApplicationIKK Inhibitor VII, CAS 873225-46-8, is a cell-permeable, potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200 nM for IKK-2, IKK complex & IKK-1, respectively).
          Biological Information
          Primary TargetIKK
          Primary Target IC<sub>50</sub>40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 22-24/25

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          401486

          References

          Reference overview
          Waelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108.

          Brochure

          Title
          Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          SynonymsIKK 16
          DescriptionA cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number873225-46-8
          Chemical formulaC₂₈H₂₉N₅OS
          Structure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesWaelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108.