401488 | IKK-3 Inhibitor IX - CAS 862812-98-4 - Calbiochem

401488
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₁₉N₃O₅S₂ 862812-98-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401488-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA thiophenecarbonitrile compound that acts as a potent ATP-competitive inhibitor of IKK-3 (IKK-ε, IC50 = 40 nM) with ~20-fold selectivity over PLK1 and more than 125-fold selectivity over a panel of 9 other commonly studied kinases, including IKK-1/2 (IKK-α/β). Reported to be inactive against cytochrome P450 isozymes (IC50 < 50 µM) 1A2, 2D6, 2C9, and 3A4.
          Catalogue Number401488
          Brand Family Calbiochem®
          Synonyms5-(5,6-Dimethoxybenzimidazol-1-yl)-3-(2-methanesulfonyl-benzyloxy)-thiophene-2-carbonitrile
          References
          ReferencesBamborough, P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6236.
          Product Information
          CAS number862812-98-4
          ATP CompetitiveY
          FormBeige solid
          Hill FormulaC₂₂H₁₉N₃O₅S₂
          Chemical formulaC₂₂H₁₉N₃O₅S₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetIKK-3
          Primary Target IC<sub>50</sub>40 nM against IKK-3 (IKK-ε)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          401488

          References

          Reference overview
          Bamborough, P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6236.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          Synonyms5-(5,6-Dimethoxybenzimidazol-1-yl)-3-(2-methanesulfonyl-benzyloxy)-thiophene-2-carbonitrile
          DescriptionA thiophenecarbonitrile compound that acts as a potent ATP-competitive inhibitor of IKK-3 (IKK-ε, IC50 = 40 nM) with ~20-fold selectivity over PLK1 and more than 125-fold selectivity over a panel of 9 other commonly studied kinases, including IKK-1/2 (IKK-α/β). Reported to be inactive against cytochrome P450 isozymes (IC50 < 50 µM) 1A2, 2D6, 2C9, and 3A4.
          FormBeige solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number862812-98-4
          Chemical formulaC₂₂H₁₉N₃O₅S₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          ReferencesBamborough, P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6236.