A part of MilliporeSigma

401482 | IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem

401482
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₈ClF₆NO₂ 978-62-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401482-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable salicylamide compound that acts as an IKK-2 inhibitor by selectively blocking IκBα phosphorylation (IC50 ~ 250 nM) and thereby prevents the induction of NF-κB p65 nuclear translocation. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC50 < 1 µM) in cardiomyocytes, and ameliorate insulin resistance in KKAy mice by regulating adiponectin release.
          Catalogue Number401482
          Brand Family Calbiochem®
          SynonymsN-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, IMD-0354
          References
          ReferencesKamon, J., et al. 2004. Biochem. Biophys. Res. Commun. 323, 242.
          Onai, Y., et al. 2004. Cardiovasc. Res. 63, 51.
          Tanaka, A., et al. 2004. Blood 105, 2324.
          Product Information
          CAS number978-62-1
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₅H₈ClF₆NO₂
          Chemical formulaC₁₅H₈ClF₆NO₂
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetIKK-2
          Primary Target IC<sub>50</sub>~ 250 nM blocking IκBα phosphorylation
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          401482

          References

          Reference overview
          Kamon, J., et al. 2004. Biochem. Biophys. Res. Commun. 323, 242.
          Onai, Y., et al. 2004. Cardiovasc. Res. 63, 51.
          Tanaka, A., et al. 2004. Blood 105, 2324.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-April-2008 JSW
          SynonymsN-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, IMD-0354
          DescriptionA cell-permeable IKK-2 inhibitor that selectively blocks IκBα phosphorylation (IC50 ~250 nM) and prevents the induction of NF-κB p65 nuclear translocation. Reported to suppress neoplastic proliferation of mast cells with constitutively activated c-kit receptor. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC50 <1 µM) in cardiomyocytes, and ameliorate insulin resistance in diabetic KKAy mice by regulating adiponectin release.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number978-62-1
          Chemical formulaC₁₅H₈ClF₆NO₂
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKamon, J., et al. 2004. Biochem. Biophys. Res. Commun. 323, 242.
          Onai, Y., et al. 2004. Cardiovasc. Res. 63, 51.
          Tanaka, A., et al. 2004. Blood 105, 2324.