407248 | IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem

407248
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₆ClN₃O₂ 196868-63-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407248-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation (IC50 = 12 µM in inhibiting ligand-induced autophosphorylation in MCF-7 cells and < 1 µM in a cell-free kinase assay). Reduces IGF-1R-dependent tumor cell growth both in vitro (IC50 = 8 and 15 µM for MCF-7 and MCNeuA, respectively) and in mice in vivo (80% reduction, 100 mg/kg thrice a week, i.p.). The mechanism of inhibition probably involves indirect blocking of ATP binding.
          Catalogue Number407248
          Brand Family Calbiochem®
          SynonymsN-(2-Methoxy-5-chlorophenyl)-Nʹ-(2-methylquinolin-4-yl)-urea, PQ401
          References
          ReferencesGable, K.L., et al. 2006. Mol. Cancer Ther. 5, 1079.
          Product Information
          CAS number196868-63-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₈H₁₆ClN₃O₂
          Chemical formulaC₁₈H₁₆ClN₃O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetIGF-1R
          Primary Target IC<sub>50</sub>12 µM in inhibiting ligand-induced IGF-1R autophosphorylation in MCF-7 cells and < 1 µM in a cell-free kinase assay; 8 and 15 µM in reducing IGF-1R-dependent tumor cell growth both in vitro for MCF-7 and MCNeuA, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407248

          References

          Reference overview
          Gable, K.L., et al. 2006. Mol. Cancer Ther. 5, 1079.

          Brochure

          Title
          Biologics 32.4 ( 1.19 MB )
          Insulin Pathway Poster PDF ( 618 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          SynonymsN-(2-Methoxy-5-chlorophenyl)-Nʹ-(2-methylquinolin-4-yl)-urea, PQ401
          DescriptionA cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation (IC50 = 12 µM in inhibiting ligand-induced autophosphorylation in MCF-7 cells and < 1 µM in a cell-free kinase assay). Reduces IGF-1R-dependent tumor cell growth both in vitro (IC50 = 8 and 15 µM for MCF-7 and MCNeuA, respectively) and in mice in vivo (80% reduction, 100 mg/kg thrice a week per i.p.). The mechanism of inhibition probably involves indirect blocking of ATP binding.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number196868-63-0
          Chemical formulaC₁₈H₁₆ClN₃O₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (3 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesGable, K.L., et al. 2006. Mol. Cancer Ther. 5, 1079.