400046 | Hydroxyurea - CAS 127-07-1 - Calbiochem

400046
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      CH₄N₂O₂ 127-07-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      400046-5GM
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          Plastic ampoule 5 gm
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          Description
          OverviewAnti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
          Catalogue Number400046
          Brand Family Calbiochem®
          SynonymsRibonucleotide Reductase Inhibitor I, RNR Inhibitor I
          References
          ReferencesLeyden, D., et al. 2000. Anticancer Res. 20, 133.
          Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
          Anand, S., et al. 1995. Cancer Lett. 88, 101.
          Product Information
          CAS number127-07-1
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaCH₄N₂O₂
          Chemical formulaCH₄N₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetInhibiting ribonucleotide reductase
          Purity>98% by elemental analysis
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSYT4900000
          Safety Information
          R PhraseR: 46-61

          May cause heritable genetic damage.
          May cause harm to the unborn child.
          S PhraseS: 45-53

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          400046

          References

          Reference overview
          Leyden, D., et al. 2000. Anticancer Res. 20, 133.
          Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
          Anand, S., et al. 1995. Cancer Lett. 88, 101.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-July-2008 RFH
          SynonymsRibonucleotide Reductase Inhibitor I, RNR Inhibitor I
          DescriptionAntineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.
          FormWhite solid
          CAS number127-07-1
          RTECSYT4900000
          Chemical formulaCH₄N₂O₂
          Structure formulaStructure formula
          Purity>98% by elemental analysis
          SolubilityH₂O (5 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 4848
          ReferencesLeyden, D., et al. 2000. Anticancer Res. 20, 133.
          Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
          Anand, S., et al. 1995. Cancer Lett. 88, 101.