390602 | Hydroxyfasudil - CAS 155558-32-0 - Calbiochem

390602
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₇N₃O₃S • HCl 155558-32-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      390602-2MG
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          Plastic ampoule 2 mg
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          Description
          OverviewA cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.
          Catalogue Number390602
          Brand Family Calbiochem®
          SynonymsROCK Inhibitor XIV, 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine, HCl, HA1100
          References
          ReferencesIto, K., et al. 2003. J. Physiol. 546, 823.
          Takemoto, M., et al. 2002. Circulation 106, 57.
          Shimokawa, H., et al. 1999. Cardiovasc. Res. 43, 1029.
          Product Information
          CAS number155558-32-0
          ATP CompetitiveY
          FormLiquid
          FormulationA 10 mM (2 mg/582 µl) solution in H₂O.
          Hill FormulaC₁₄H₁₇N₃O₃S • HCl
          Chemical formulaC₁₄H₁₇N₃O₃S • HCl
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetRho-kinase
          Primary Target IC<sub>50</sub>0.9 and 1.8 µM against Rho-kinase using a peptide and MLC as substrate, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          390602

          References

          Reference overview
          Ito, K., et al. 2003. J. Physiol. 546, 823.
          Takemoto, M., et al. 2002. Circulation 106, 57.
          Shimokawa, H., et al. 1999. Cardiovasc. Res. 43, 1029.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-March-2008 JSW
          SynonymsROCK Inhibitor XIV, 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine, HCl, HA1100
          DescriptionA cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.
          FormLiquid
          FormulationA 10 mM (2 mg/582 µl) solution in H₂O.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number155558-32-0
          Chemical formulaC₁₄H₁₇N₃O₃S • HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Harmful
          ReferencesIto, K., et al. 2003. J. Physiol. 546, 823.
          Takemoto, M., et al. 2002. Circulation 106, 57.
          Shimokawa, H., et al. 1999. Cardiovasc. Res. 43, 1029.