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14-1067 | Human Recombinant MeCP2 (methyl-CpG-binding protein 2)

10 µg  
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      Replacement Information
      Catalogue Number14-1067
      DescriptionHuman Recombinant MeCP2 (methyl-CpG-binding protein 2)
      OverviewHuman recombinant N-terminal His-tagged MeCP2 expressed in SF9 insect cells and purified by Fast Protein Liquid Chromatography (FPLC).
      Background InformationMeCP2 (methyl-CpG-binding protein 2) binds methylated CpG sequences in double-stranded DNA resulting in the suppression of transcription. This protein is likely to be involved in the repression of multiple genes. Consistent with this role, mutations of MeCP2 are linked to Rett syndrome, a progressive neurological disorder that is one of the most common causes of mental retardation in females.
      Product Information
      PresentationIn a buffer containing 20 mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.
      ApplicationHuman recombinant N-terminal His-tagged MeCP2 expressed in SF9 insect cells & purified by Fast Protein Liquid Chromatography (FPLC) & demonstrated to bind methylated DNA
      Key Applications
      • DNA-binding Proteins
      Biological Information
      Concentration0.5 µg/µL
      PurityGreater than 95% purity by SDS PAGE
      Molecular Weight50.2 kDa including histidine tag
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable at -80ºC for 6 months from date of receipt.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information