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CC1022 | Human Integrin αVβ5, Octyl-β-D-glucopyranoside Formulation

CC1022
25 µg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberCC1022
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionHuman Integrin αVβ5, Octyl-β-D-glucopyranoside Formulation
      OverviewIntegrin alphaVbeta5 was purified from human placenta by affinity chromatography using immobilized monoclonal antibodies to alphaVbeta5 integrin.
      References
      Product Information
      PresentationPurified protein inTris buffered saline with 100mM Octyl-β-D-glucopyranoside and sodium azide
      Applications
      Key Applications
      • Positive Control
      Application NotesElectrophoresis

      Immunoblotting

      Ligand binding studies. This format of alphaVbeta5 is appropriate for functional evaluation.

      Optimal working dilutions must be determined by end user.
      Biological Information
      Concentration433 μg/mL
      Purity>95% by SDS-PAGE (silver stain)
      Entrez Gene Number
      Entrez Gene SummaryITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
      Gene Symbol
      • ITGAV
      • DKFZp686A08142
      • MSK8
      • CD51
      • VNRA
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
      SIZE: 1048 amino acids; 116038 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -70°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/ thaw cycles.
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      HUMAN INTEGRIN alphaVbeta5 -2638909 2638909
      HUMAN INTEGRIN alphaVbeta5 -2755739 2755739
      HUMAN INTEGRIN alphaVbeta5 OCTYL--D-GLUCOPYRANOSIDE FORMULATION PURIFIED PROTEIN - 2199572 2199572
      HUMAN INTEGRIN alphaVbeta5 OCTYL--D-GLUCOPYRANOSIDE FORMULATION PURIFIED PROTEIN - 2271133 2271133
      HUMAN INTEGRIN alphaVbeta5, OCTYL-β-D-GLUCOPYRANOSIDE FORMULATION, PURIFIED PROTEIN 2832912

      Data Sheet

      Title
      Human Integrin alphaVbeta5, Octyl-beta-D-glucopyranoside Formulation - Data Sheet