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HCP-20K | Human C-Peptide RIA

250 tubes  
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      Replacement Information

      Key Specifications Table

      Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
      C-Peptide H RIA Radioactive, 125I
      Catalogue NumberHCP-20K
      DescriptionHuman C-Peptide RIA
      Background InformationC-peptide is a byproduct of normal insulin production by the beta cells in the pancreas and correlates directly to endogenous concentrations of insulin.
      Product Information
      Detection methodRadioactive 125I
      • ED80 = 0.3 ± 0.1 ng/mL
        ED50 = 1.1 ± 0.1 ng/mL
        ED20 = 4.1 ± 0.4 ng/mL
      ApplicationThis radioimmunoassay (RIA) measures & quantifies C-Peptide for use in Metabolism & Endocrine research.
      Key Applications
      • Radioimmunoassay
      Application NotesOvernight, equilibrium incubation at 4°C. Sample volume < 100 μL serum, plasma, or tissue culture media.
      Biological Information
      Species Reactivity
      • Human
      Analytes Available
      • C-Peptide
      Entrez Gene Number
      Entrez Gene SummaryAfter removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
      Gene Symbol
      • INS
      • proinsulin
      • insulin
      Radioactive Isotype125I-Human C-Peptide
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01308 # Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
      SIZE: 110 amino acids; 11981 Da
      SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
      DISEASE:SwissProt: P01308 # Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
      SIMILARITY: SwissProt: P01308 ## Belongs to the insulin family.
      Physicochemical Information
      • 0.1 ng/mL
      Standard Curve Range
      • 0.1–5 ng/mL
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size250 tubes
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 


      Reference overviewPub Med ID
      Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients.
      V T T Huyen,D V Phan,P Thang,P T Ky,N K Hoa,C G Ostenson
      Evidence-based complementary and alternative medicine : eCAM 2012 2012

      Show Abstract
      23125867 23125867
      Islet autoimmunity status in Asians with young-onset diabetes (12-40 years): association with clinical characteristics, beta cell function and cardio-metabolic risk factors.
      A C Thai,V Mohan,B A K Khalid,C S Cockram,C Y Pan,P Zimmet,J P Yeo,
      Diabetes research and clinical practice 80 2008

      Show Abstract
      18207602 18207602
      Sensitive quantitative analysis of C-peptide in human plasma by 2-dimensional liquid chromatography-mass spectrometry isotope-dilution assay.
      Eduard Rogatsky, Beate Balent, Gayotri Goswami, Vlad Tomuta, Harsha Jayatillake, Greg Cruikshank, Louis Vele, Daniel T Stein
      Clinical chemistry 52 872-9 2006

      Show Abstract
      16556683 16556683


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