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384620 | Honokiol - CAS 35354-74-6 - Calbiochem

384620
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₈O₂ 35354-74-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      384620-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking VEGFR2 autophosphorylation and subsequent rac activation. Also blocks the in vivo growth of SVR angiosarcoma in nude mice.
          Catalogue Number384620
          Brand Family Calbiochem®
          Synonyms5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV
          References
          ReferencesBai, X., et al. 2003. J. Biol. Chem. 278, 35501.
          Yang, S.E., et al. 2002. Biochem. Pharmacol. 63, 1641.
          Son, H.J., et al. 2000. Planta Med. 66, 469.
          Maruyama, Y., et al. 1998. J. Nat. Prod. 61, 135.
          Product Information
          CAS number35354-74-6
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₈H₁₈O₂
          Chemical formulaC₁₈H₁₈O₂
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetAnti-angiogenic, anti-tumor and anxiolytic properties
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          384620

          References

          Reference overview
          Bai, X., et al. 2003. J. Biol. Chem. 278, 35501.
          Yang, S.E., et al. 2002. Biochem. Pharmacol. 63, 1641.
          Son, H.J., et al. 2000. Planta Med. 66, 469.
          Maruyama, Y., et al. 1998. J. Nat. Prod. 61, 135.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-May-2008 RFH
          Synonyms5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV
          DescriptionThe active principle of Magnolia extracts that exhibits anti-angiogenic, anti-tumor, anxiolytic, and chemoprotective properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking vascular endothelial growth factor receptor 2 (VEGFR2) autophosphorylation and subsequent rac activation. Also shown to block the growth of SVR angiosarcoma in nude mice.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number35354-74-6
          Chemical formulaC₁₈H₁₈O₂
          Structure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 4742
          ReferencesBai, X., et al. 2003. J. Biol. Chem. 278, 35501.
          Yang, S.E., et al. 2002. Biochem. Pharmacol. 63, 1641.
          Son, H.J., et al. 2000. Planta Med. 66, 469.
          Maruyama, Y., et al. 1998. J. Nat. Prod. 61, 135.