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17-330 | Histone Methyltransferase Assay Reagent Kit

17-330
1 kit  Kit capacity: 100 assays
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      Overview

      Replacement Information

      Key Specifications Table

      Key Applications
      HMT
      Description
      Catalogue Number17-330
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionHistone Methyltransferase Assay Reagent Kit
      OverviewAccessory reagent kit for the analysis of histone methyltransferase activity.
      References
      Product Information
      Components
      • 5X HMTase Assay Buffer
      • Core histones
      • P81 Phosphocellulose Squares (Cat.# 20-134)
      Applications
      ApplicationAccessory reagent kit for the analysis of histone methyltransferase activity.
      Key Applications
      • Histone Methyltransferase Assay (HMT)
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryIn mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
      Gene Symbol
      • HNMT
      • HMT
      • HNMT-S2
      • HNMT-S1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P50135 # Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
      SIZE: 292 amino acids; 33295 Da
      SUBUNIT: Monomer.
      SUBCELLULAR LOCATION: Cytoplasm.
      SIMILARITY: SwissProt: P50135 ## Belongs to the methyltransferase superfamily. HNMT family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by methylating core histones with PRMT1, active (14-474).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size1 kit
      Material PackageKit capacity: 100 assays
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      HMT Assay Reagent Kit 2459582
      HMT Assay Reagent Kit - 2389525 2389525
      HMT Assay Reagent Kit - 1959299 1959299
      HMT Assay Reagent Kit - DAM1643634 DAM1643634
      HMT Assay Reagent Kit - DAM1778061 DAM1778061
      HMT Assay Reagent Kit - JBC1838322 JBC1838322
      Histone Methyltransferase Assay Reagent Kit - 22371 22371
      Histone Methyltransferase Assay Reagent Kit - 26584 26584
      Histone Methyltransferase Assay Reagent Kit - 32198 32198

      Brochure

      Title
      Product Selection Guide - Antibodies, small molecule inhibitors, kits, assays and proteins for signaling research.

      Related Products & Applications

      Kit Component

      Catalog Number Description  
      20-134 P81 Phosphocellulose Squares Show Pricing & Availability

      Categories

      Life Science Research > Protein Detection and Quantification > Activity Assays > HAT & HDAC Assay Kits