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373385 | Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem

373385
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₈N₄OS 315703-52-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      373385-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable imidazopyridine compound that acts as downstream Hedgehog (Hh) pathway blocker by directly targeting the enzymatic activity of Adh7 (IC50 = 210 nM), the class IV alcohol dehydrogenase. Inhibits Hg-Ag-induced Gli-transcription activity (IC50 = 30 nM) as well as Gli1 and Ptc1 mRNA expression in a dose-dependent manner in H3H10T1/2 cells. Shown to exhibit ≥100-fold greater cytotoxicity towards five Hh activated tumor cells (GI50 ≤21 nM vs. 1.6 µM for the non-Hh activated H3H10T1/2 cells) in vitro and inhibit the growth of two xenografted tumors in mice (30-50% inhibition, 0.2 mg/mouse/day by p.o.) in vivo. Also acts as a microtubule-depolymerizing agent.
          Catalogue Number373385
          Brand Family Calbiochem®
          SynonymsN-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
          References
          ReferencesCupido, T., et al. 2009. Angew Chem. 48, in press.
          Lee, J., et al. 2007. ChemBioChem. 8, 1916.
          Product Information
          CAS number315703-52-7
          FormPink solid
          Hill FormulaC₁₉H₁₈N₄OS
          Chemical formulaC₁₉H₁₈N₄OS
          Structure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          373385

          References

          Reference overview
          Cupido, T., et al. 2009. Angew Chem. 48, in press.
          Lee, J., et al. 2007. ChemBioChem. 8, 1916.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-March-2009 JSW
          SynonymsN-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
          DescriptionA cell-permeable imidazopyridine compound that acts as downstream Hedgehog (Hh) pathway blocker by directly targeting the enzymatic activity of Adh7 (IC50 = 210 nM), the class IV alcohol dehydrogenase. Inhibits Hg-Ag-induced Gli-transcription activity (IC50 = 30 nM) as well as Gli1 and Ptc1 mRNA expression in a dose-dependent manner in H3H10T1/2 cells. Shown to exhibit ≥100-fold greater cytotoxicity towards five Hh activated tumor cells (GI50 ≤21 nM vs. 1.6 µM for the non-Hh activated H3H10T1/2 cells) in vitro and inhibit the growth of two xenografted tumors in mice (30-50% inhibition, 0.2 mg/mouse/day by p.o.) in vivo. Also acts as a microtubule-depolymerizing agent.
          FormPink solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number315703-52-7
          Chemical formulaC₁₉H₁₈N₄OS
          Structure formula
          Purity≥98% by HPLC
          SolubilityDMSO (40 mg/ml) or Methanol (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
          Toxicity Standard Handling
          ReferencesCupido, T., et al. 2009. Angew Chem. 48, in press.
          Lee, J., et al. 2007. ChemBioChem. 8, 1916.