376817 | Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3 - Calbiochem

376817
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃H₃BrO₃ 1113-59-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      376817-100MG
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          100 mg
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          Description
          OverviewA cell-permeable pyruvic acid derivative that acts as an inhibitor against hexokinase II-mediated glycolysis and effectively suppress tumor survival both in cultures in vitro and in mice and rats in vivo.
          Catalogue Number376817
          Brand Family Calbiochem®
          Synonyms3-BrPA, Bromopyruvate, Bromopyruvatic Acid, 3-Bromo-2-oxopropionic acid
          References
          ReferencesBujis, M., et al. 2009. Invest. New Drugs 27, 120.
          Chen, Z., et al. 2009. Biochim. Biophys. Acta. 1787, 553.
          Hulleman, E., et al. 2009. Blood. 113, 2014;
          Mathupala, S.P., et al. 2009. Semin. Cancer Biol. 19, 17.
          Pereira da Silva, A.P., et al. 2009. Biochem. J. 417, 717.
          Yun, J., et al. 2009. Science. 325, 1555.
          Zhang, X., et al. 2009. Anticancer Res. 29, 1443.
          Kim, J.S., et al. 2008. J. Bioenerg. Biomembr. 40, 607.
          Product Information
          CAS number1113-59-3
          EC number214-206-5
          FormWhite crystalline solid
          Hill FormulaC₃H₃BrO₃
          Chemical formulaC₃H₃BrO₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by Titration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUZ0840000
          Safety Information
          R PhraseR: 34

          Causes burns.
          S PhraseS: 26-36/37/39-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Corrosive
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          376817

          References

          Reference overview
          Bujis, M., et al. 2009. Invest. New Drugs 27, 120.
          Chen, Z., et al. 2009. Biochim. Biophys. Acta. 1787, 553.
          Hulleman, E., et al. 2009. Blood. 113, 2014;
          Mathupala, S.P., et al. 2009. Semin. Cancer Biol. 19, 17.
          Pereira da Silva, A.P., et al. 2009. Biochem. J. 417, 717.
          Yun, J., et al. 2009. Science. 325, 1555.
          Zhang, X., et al. 2009. Anticancer Res. 29, 1443.
          Kim, J.S., et al. 2008. J. Bioenerg. Biomembr. 40, 607.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-December-2010 RFH
          Synonyms3-BrPA, Bromopyruvate, Bromopyruvatic Acid, 3-Bromo-2-oxopropionic acid
          DescriptionA cell-permeable pyruvic acid derivative that acts as an inhibitor against hexokinase II-mediated glycolysis and effectively suppress tumor survival both in cultures in vitro and in mice and rats in vivo.
          FormWhite crystalline solid
          CAS number1113-59-3
          RTECSUZ0840000
          EC number214-206-5
          Chemical formulaC₃H₃BrO₃
          Structure formulaStructure formula
          Purity≥97% by Titration
          SolubilityDMSO (100 mg/ml) or dH₂O (100 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Corrosive
          ReferencesBujis, M., et al. 2009. Invest. New Drugs 27, 120.
          Chen, Z., et al. 2009. Biochim. Biophys. Acta. 1787, 553.
          Hulleman, E., et al. 2009. Blood. 113, 2014;
          Mathupala, S.P., et al. 2009. Semin. Cancer Biol. 19, 17.
          Pereira da Silva, A.P., et al. 2009. Biochem. J. 417, 717.
          Yun, J., et al. 2009. Science. 325, 1555.
          Zhang, X., et al. 2009. Anticancer Res. 29, 1443.
          Kim, J.S., et al. 2008. J. Bioenerg. Biomembr. 40, 607.