373260 | Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem

373260
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃H₁₁NO₄ 218924-25-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      373260-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK.
          Catalogue Number373260
          Brand Family Calbiochem®
          SynonymsKNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I
          References
          ReferencesKoishi, M., et al. 2001. Clin. Cancer Res. 7, 215.
          Yokota, S., et al. 2000. Cancer Res. 60, 2942.
          Product Information
          CAS number218924-25-5
          ATP CompetitiveN
          FormWhite to light yellow powder
          Hill FormulaC₁₃H₁₁NO₄
          Chemical formulaC₁₃H₁₁NO₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetHsp70
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          373260

          References

          Reference overview
          Koishi, M., et al. 2001. Clin. Cancer Res. 7, 215.
          Yokota, S., et al. 2000. Cancer Res. 60, 2942.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          SynonymsKNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I
          DescriptionA benzylidine lactam compound that inhibits the induction of heat shock proteins, including HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner, but does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600), and, unlike quercetin, it does not affect the activities of PKA, PKC, and PTK.
          FormWhite to light yellow powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number218924-25-5
          Chemical formulaC₁₃H₁₁NO₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (3 mg/ml) or Olive oil
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.
          Toxicity Harmful
          ReferencesKoishi, M., et al. 2001. Clin. Cancer Res. 7, 215.
          Yokota, S., et al. 2000. Cancer Res. 60, 2942.