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14-593M | HePTP Protein, 250 µg

250 µg  Also available in 10 μg size (cat#14-593) and in bulk (cat# 14-593-K).
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      Replacement Information
      Catalogue Number14-593M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionHePTP Protein, 250 µg
      OverviewN-terminal His6-tagged, recombinant human HePTP, amino acid residues 22- end
      Product Information
      ApplicationN-terminal His6-tagged, recombinant human HePTP, amino acid residues 22-end, for use in Phosphatase Assays.
      Key Applications
      • Phosphatase Assay
      Biological Information
      Sourceexpressed in E. coli
      Specific ActivityFor Specific Activity Data, refer to the Certificate of Analysis for individual lots of this enzyme
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • PTPN7
      • BPTP-4
      • LC-PTP
      • LPTP
      • HEPTP
      • PTPNI
      Protein TargetHePTP
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTyr phosphatase
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P35236 # Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
      SIZE: 360 amino acids; 40529 Da
      SUBUNIT: Monomer. Interacts with MAPK1, MAPK3 and several other MAP kinases.
      TISSUE SPECIFICITY: Expressed exclusively in thymus and spleen.
      PTM: Phosphorylated on serine residues in resting T-cells. Phosphorylation increases upon exposure to stimuli that increase intracellular cAMP levels. Phosphorylation leads to dissociation of bound MAP kinases.
      SIMILARITY: SwissProt: P35236 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. & Contains 1 tyrosine-protein phosphatase domain.
      Molecular Weight40.7kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by dephosphorylation of 100μM DiFMUP
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-593) and in bulk (cat# 14-593-K).
      Transport Information
      Supplemental Information


      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-593 HePTP Protein, 10 µg Show Pricing & Availability

      Product Families


      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Phosphatases
      Life Science Research > Proteins and Enzymes > Purified Phosphatases