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397100 | HNMPA-(AM)₃ - CAS 120944-03-8 - Calbiochem

397100
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₃O₁₀P 120944-03-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      397100-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable analog of HNMPA that yields the parent compound upon cleavage by cytosolic esterases. Inhibits insulin receptor tyrosine kinase (IC50 = 100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50 = 10 µM). Also reported to inhibit tyrosine autophosphorylation of the human insulin receptor (IC50 = 200 µM).
          Catalogue Number397100
          Brand Family Calbiochem®
          SynonymsHydroxy-2-naphthalenylmethylphosphonic Acid Trisacetoxymethyl Ester, Pro-drug II
          References
          ReferencesBaltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 7885.
          Saperstein, R., et al. 1989. Biochemistry 28, 5694.
          Product Information
          CAS number120944-03-8
          ATP CompetitiveN
          FormColorless oil
          Hill FormulaC₂₀H₂₃O₁₀P
          Chemical formulaC₂₀H₂₃O₁₀P
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary Targettyrosine kinase
          Primary Target IC<sub>50</sub>100 µM and 10 µM against insulin receptor tyrosine kinase and insulin-stimulated glucose oxidation in isolated rat adipocytes, respectively
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          397100

          References

          Reference overview
          Baltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 7885.
          Saperstein, R., et al. 1989. Biochemistry 28, 5694.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          SynonymsHydroxy-2-naphthalenylmethylphosphonic Acid Trisacetoxymethyl Ester, Pro-drug II
          DescriptionA cell-permeable analog of HNMPA. Inhibits insulin receptor tyrosine kinase (IC50 = 100 mM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50 = 10 µM). Also reported to inhibit tyrosine autophosphorylation of the human insulin receptor (IC50 = 200 µM). It has no effect on PKA (at concentrations up to 1 mM) or PKC (at concentrations up to 420 µM).
          FormColorless oil
          CAS number120944-03-8
          Chemical formulaC₂₀H₂₃O₁₀P
          Structure formula
          Purity≥98% by TLC
          SolubilityDMSO (20 mg/ml) or Ethanol (20 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBaltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 7885.
          Saperstein, R., et al. 1989. Biochemistry 28, 5694.