534337 HIV Inhibitor, CADA - Calbiochem

534337
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₁H₃₉N₃O₄S₂·HCl

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.34337.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable macrocyle cyclotriazadisulfonamide derivative compound that inhibits HIV replication (IC50 = 300 nM to 3.3 µM) and entry into cells by blocking co-translational translocation of nascent CD4 across endoplasmic reticulum membranes. Its action appears to be highly selective in reducing the expression of human CD4 and it does not affect the level of any other cell surface marker studied. Does not affect CD4 mRNA levels in cells. Shown to be effective against HIV-1 subtypes A to H, AE, and O and human herpesvirus 7 (HHV-7; IC50, 300 nM to 1.5 µM) in T-cell lines and PBMCs. Also reported to block X4 HIV-1 NL4.3 and R5 SIVmac251 laboratory strains infection in human T cells. Can act synergistically with cellulose acetate phthalate (CAP) and other anti-HIV drugs to inhibit HIV-1 and SIV infections.
          Catalogue Number534337
          Brand Family Calbiochem®
          Synonyms1-Benzyl-7-methylene-5,9-ditosyl-5,9-diaza-azoniacyclododecan-1-ium chloride, CD4 Inhibitor, CADA
          References
          ReferencesVermeire, K., et al. 2008. Curr. HIV Res. 6, 246.
          Bell, T. W., et al. 2006. J. Med. Chem. 49, 1291.
          Vermeire, K., et al. 2004. AIDS. 18, 2115.
          Vermeire, K., et al. 2002. Virology. 302, 342.
          Product Information
          FormWhite solid
          Hill FormulaC₃₁H₃₉N₃O₄S₂·HCl
          Chemical formulaC₃₁H₃₉N₃O₄S₂·HCl
          ReversibleY
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          HIV Inhibitor, CADA - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Vermeire, K., et al. 2008. Curr. HIV Res. 6, 246.
          Bell, T. W., et al. 2006. J. Med. Chem. 49, 1291.
          Vermeire, K., et al. 2004. AIDS. 18, 2115.
          Vermeire, K., et al. 2002. Virology. 302, 342.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-July-2017 JSW
          Synonyms1-Benzyl-7-methylene-5,9-ditosyl-5,9-diaza-azoniacyclododecan-1-ium chloride, CD4 Inhibitor, CADA
          DescriptionA cell-permeable macrocyle cyclotriazadisulfonamide derivative compound that inhibits HIV replication (IC50 = 300 nM to 3.3 µM) and entry into cells by blocking co-translational translocation of nascent CD4 across endoplasmic reticulum membranes. Its action appears to be highly selective in reducing the expression of human CD4 and it does not affect the level of any other cell surface marker studied. Does not affect CD4 mRNA levels in cells. Shown to be effective against HIV-1 subtypes A to H, AE, and O and human herpesvirus 7 (HHV-7; IC50, 300 nM to 1.5 µM) in T-cell lines and PBMCs. Also reported to block X4 HIV-1 NL4.3 and R5 SIVmac251 laboratory strains infection in human T cells. Can act synergistically with cellulose acetate phthalate (CAP) and other anti-HIV drugs to inhibit HIV-1 and SIV infections.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₁H₃₉N₃O₄S₂·HCl
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml). Insoluble in water.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesVermeire, K., et al. 2008. Curr. HIV Res. 6, 246.
          Bell, T. W., et al. 2006. J. Med. Chem. 49, 1291.
          Vermeire, K., et al. 2004. AIDS. 18, 2115.
          Vermeire, K., et al. 2002. Virology. 302, 342.