400086 | HIF Inhibitor VI - Calbiochem

400086
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₇H₃₄N₂O₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      400086-5MG
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      Stocked 
      Discontinued
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      Available
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable emetan derivative that selectively reduces HIF-1 activity by 73% in a luciferase reporter assay, and blocks HIF-1α protein induction in response to DFX, hypoxia, and IGF-1 in U2OS-HRE-luc cells at 10 µM, without significantly inhibiting cell growth. Furthermore, it is shown to completely block HIF-1α induced by IGF-1 in HCT116 human colon carcinoma cells.
          Catalogue Number400086
          Brand Family Calbiochem®
          SynonymsNSC-134754
          References
          ReferencesChau, N.M., et al. 2005. Cancer Res. 65, 4918.
          Product Information
          FormBrown solid
          Hill FormulaC₂₇H₃₄N₂O₂
          Chemical formulaC₂₇H₃₄N₂O₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥90% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          400086

          References

          Reference overview
          Chau, N.M., et al. 2005. Cancer Res. 65, 4918.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-January-2013 JSW
          SynonymsNSC-134754
          DescriptionA cell-permeable emetan derivative that selectively reduces HIF-1 activity by 73% in a luciferase reporter assay, and blocks HIF-1α protein induction in response to DFX, hypoxia, and IGF-1 in U2OS-HRE-luc cells at 10 µM, without significantly inhibiting cell growth. Furthermore, it is shown to completely block HIF-1α induced by IGF-1 in HCT116 human colon carcinoma cells.
          FormBrown solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₇H₃₄N₂O₂
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesChau, N.M., et al. 2005. Cancer Res. 65, 4918.