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373210 | HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem

373210
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₂₃N₃S 321673-30-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      373210-25MG
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      Stocked 
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      Available
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          25 mg
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          Description
          OverviewA cell-permeable thiosemicarbazone copper chelator that potently blocks the HDL receptor SR-BI- (scavenger receptor, class B, type I) mediated lipid uptake (IC50 = 21 and 57 nM against DiI and CE uptake, respectively, from DiI-HDL and CE-HDL using hamster ldlA-7 cells expressing murine SR-BI) in a reversible manner, while exerting little effect toward intracellular membrane trafficking or cytoskeletal organization. BLT-1 chelates Cu+2 in a 2:1 stoichiometric ratio and a half molar equivalent of CuCl2 is shown to fully prevent zebrafish embryos from BLT-1-induced development defects, while BLT-1 can likewise be used to chelate excess amount of copper (>4 µM) and rescue embryos from copper toxicity.
          Catalogue Number373210
          Brand Family Calbiochem®
          SynonymsBlock Lipid Transport-1, 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20
          References
          ReferencesNieland, T.J.F., et al. 2008. Biochemistry 47, 460.
          Raldua, D., and Babin, P.J. 2007. Toxicol. Lett. 175, 1.
          Nieland, T.J.F., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 15422.
          Peterson, R.T., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 12965.
          Product Information
          CAS number321673-30-7
          FormWhite solid
          Hill FormulaC₁₂H₂₃N₃S
          Chemical formulaC₁₂H₂₃N₃S
          Structure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          373210

          References

          Reference overview
          Nieland, T.J.F., et al. 2008. Biochemistry 47, 460.
          Raldua, D., and Babin, P.J. 2007. Toxicol. Lett. 175, 1.
          Nieland, T.J.F., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 15422.
          Peterson, R.T., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 12965.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          SynonymsBlock Lipid Transport-1, 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20
          DescriptionA cell-permeable thiosemicarbazone copper chelator that potently blocks the HDL receptor SR-BI- (scavenger receptor, class B, type I) mediated lipid uptake (IC50 = 21 and 57 nM against DiI and CE uptake, respectively, from DiI-HDL and CE-HDL using hamster ldlA-7 cells expressing murine SR-BI) in a reversible manner, while exerting little effect toward intracellular membrane trafficking or cytoskeletal organization. BLT-1 chelates Cu+2 in a 2:1 stoichiometric ratio and a half molar equivalent of CuCl2 is shown to fully prevent zebrafish embryos from BLT-1-induced development defects, while BLT-1 can likewise be used to chelate excess amount of copper (>4 µM) and rescue embryos from copper toxicity.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number321673-30-7
          Chemical formulaC₁₂H₂₃N₃S
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesNieland, T.J.F., et al. 2008. Biochemistry 47, 460.
          Raldua, D., and Babin, P.J. 2007. Toxicol. Lett. 175, 1.
          Nieland, T.J.F., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 15422.
          Peterson, R.T., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 12965.