508194 | HDAC6 Inhibitor III - Calbiochem

508194
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₀H₁₉N₃O₃

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08194.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable, quinazolin-4-one based hydroxamic acid containing compound that acts as a potent and selective inhibitor of histone deacetylase 6 (HDAC6; IC50 = 29 nM). Exhibits high selectivity over other HDACs (IC50 = 1.88, 6.45, 1.75, and 4.08 µM for HDAC1, 2, 8, and 11, respectively). Does not affect hERG activity (>10 µM) or p450 activity (IC50 > 6.5 µM). Blocks b-amyloid (Ab) aggregation in the presence of zinc (IC50 = 9.5 µM) and improves learning-based performance in mice. Induces neurite outgrowth (EC50 = 7.3 and 9.2 µM in PC12 and SH-SY5Y cells, respectively) and enhances synaptic activity (EC50 = 6.5 and 6.8 µM in PC12 and SH-SY5Y cells, respectively). Shown to enhance acetylated a-tubulin levels in hippocampus region of mice with Ab lesions.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number508194
          Brand Family Calbiochem®
          References
          ReferencesYu, C.W., et al. 2013. J. Med. Chem. 56, 6775.
          Product Information
          FormCream powder
          Hill FormulaC₂₀H₁₉N₃O₃
          Chemical formulaC₂₀H₁₉N₃O₃
          ReversibleY
          Applications
          Biological Information
          Primary TargetHDAC6
          Primary Target IC<sub>50</sub>29 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Yu, C.W., et al. 2013. J. Med. Chem. 56, 6775.

          Technical Info

          Title
          White Paper - The Message in the Marks: Deciphering Cancer Epigenetics (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2014 JSW
          DescriptionA cell-permeable, quinazolin-4-one based hydroxamic acid containing compound that acts as a potent and selective inhibitor of histone deacetylase 6 (HDAC6; IC50 = 29 nM). Exhibits high selectivity over other HDACs (IC50 = 1.88, 6.45, 1.75, and 4.08 µM for HDAC1, 2, 8, and 11, respectively). Does not affect hERG activity (>10 µM) or p450 activity (IC50 > 6.5 µM). Blocks b-amyloid (Ab) aggregation in the presence of zinc (IC50 = 9.5 µM) and improves learning-based performance in mice. Induces neurite outgrowth (EC50 = 7.3 and 9.2 µM in PC12 and SH-SY5Y cells, respectively) and enhances synaptic activity (EC50 = 6.5 and 6.8 µM in PC12 and SH-SY5Y cells, respectively). Shown to enhance acetylated a-tubulin levels in hippocampus region of mice with Ab lesions.
          FormCream powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₀H₁₉N₃O₃
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesYu, C.W., et al. 2013. J. Med. Chem. 56, 6775.