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14-838 | HDAC1, active recombinant protein

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      Replacement Information

      Key Specifications Table

      Key ApplicationsEntrez Gene NumberSpeciesUni Prot Number
      WB, EA NP_004955.2 Human Q13547
      Catalogue Number14-838
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionHDAC1, active recombinant protein
      OverviewRecominant human HDAC1 with C-terminal 6His-tag
      Background InformationHistone deacetylation acts a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDAC1 is part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, Rbbp4 and Rbbp7, which deacetylates lysines on the core histones. The core complex associates with a wide variety of other proteins to form multiprotein complexes, including the nucleosome remodeling complex, the nurd complex, and the sin3 HDAC complex. HDAC1 also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
      Product Information
      Presentation50 μg of recombinant protien in 50 mM Tris-HCl, pH 8.0, 150 mM NaCl, 20% glycerol. Frozen solution.
      ApplicationRecominant human HDAC1 with C-terminal 6His-tag.
      Key Applications
      • Western Blotting
      • Enzyme Assay
      Application NotesHDAC deacetylase assays
      Biological Information
      Concentration0.5 mg/ml
      PurityPurity >45% by SDS-PAGE and Coomassie blue staining.
      SourceExpressed by baculovirus in Sf9 insect cells.
      Specific Activity[Varies with lot. For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.] Lot R0803D0006: 22 U/mg, where one unit of HDAC1 activity is defined as 1 nmol of assay substrate (HDAC assay kit, catalog #17-356) deacetylated per minute at 37°C.
      Entrez Gene Number
      Purification MethodProBond Resin chromatography
      UniProt Number
      Molecular Weight56 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceHDAC1 Deacetylase Assay: 2 µg of this lot of enzyme deacetylated 100 µM assay substrate using the HDAC Assay Kit, Catalog # 17-356
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in aliquots at -70°C. Avoid freeze/thaw cycles. For maximum recovery of product, centrifuge original vial prior to removing cap.
      Packaging Information
      Material Size1 each
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      HDAC1, active (recombinant protein expressed in Sf9 cells) - 2033774 2033774
      HDAC1, active (recombinant protein expressed in Sf9 cells) - 2204408 2204408
      HDAC1, active (recombinant protein expressed in Sf9 cells) -2379773 2379773
      HDAC1, active - R0803D0006 R0803D0006
      HDAC1, active -2595384 2595384


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      Life Science Research > Proteins and Enzymes > Other Enzymes