382181 | HDAC Inhibitor XXIV, OSU-HDAC-44 - Calbiochem

382181
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₉H₂₂N₂O₃

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      382181-10MG
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      Stocked 
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      Available
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable, phenylbutyrate hydroxamate pan-HDAC inhibitor that is shown to suppress the activities of class I (HDAC1 and HDAC8), class II (HDAC4 and HDAC6), and class IV (HDAC11) HDACs by > ~90% compared to control, at a concentration of 1 µM with a comparable or greater inhibitory effect than SAHA. In vitro, this compound exhibits a broad spectrum of anti-tumor activities in NSCLC cells, holds synergistic effects with cisplatin in the reduction of cell viability, is implicated in the induction of the intrinsic apoptotic pathway, and displays inhibitory effects against mitosis and cytokinesis. This inhibitor is also shown to suppress tumor growth in mice genograft models by 62%, 78% and 90% at 7.5, 15 and 30 mg/kg respectively without adversely affect in body weight and detectable toxicity.
          Catalogue Number382181
          Brand Family Calbiochem®
          SynonymsOSU-HDAC-44
          References
          ReferencesTang, Y., et al. 2010. PLoS One 5, e12417.
          Product Information
          FormOff-white solid
          Hill FormulaC₁₉H₂₂N₂O₃
          Chemical formulaC₁₉H₂₂N₂O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          382181

          References

          Reference overview
          Tang, Y., et al. 2010. PLoS One 5, e12417.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-March-2011 RFH
          SynonymsOSU-HDAC-44
          DescriptionA cell-permeable, phenylbutyrate hydroxamate pan-HDAC inhibitor that is shown to suppress the activities of class I (HDAC1 and HDAC8), class II (HDAC4 and HDAC6), and class IV (HDAC11) HDACs by > ~90% compared to control, at a concentration of 1 µM with a comparable or greater inhibitory effect than SAHA. In vitro, this compound exhibits a broad spectrum of anti-tumor activities in NSCLC cells, holds synergistic effects with cisplatin in the reduction of cell viability, is implicated in the induction of the intrinsic apoptotic pathway, and displays inhibitory effects against mitosis and cytokinesis. This inhibitor is also shown to suppress tumor growth in mice genograft models by 62%, 78% and 90% at 7.5, 15 and 30 mg/kg respectively without adversely affect in body weight and detectable toxicity.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₉H₂₂N₂O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (20 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTang, Y., et al. 2010. PLoS One 5, e12417.