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371970 | HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem

371970
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₇N₃O₂S · 2HCl 103745-39-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      371970-1MG
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          Glass bottle 1 mg
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          Description
          OverviewA cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), and myosin light chain kinase (Ki = 36 µM). Also reported to potently inhibit Rho-associated kinase (ROCK; IC50 = 10.7 µM). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
          Catalogue Number371970
          Brand Family Calbiochem®
          SynonymsFasudil, (5-Isoquinolinesulfonyl)homopiperazine, 2HCl, PKG Inhibitor VII
          References
          ReferencesWatanabe, K., et al. 2007. Nature Biotech. 25, 681.
          Swärd, K., et al. 2000. J. Physiol. 522, 33.
          Takizawa, S., et al. 1993. Eur. J. Pharmacol. 250, 431.
          Seto, M., et al. 1991. Eur. J. Pharmacol. 195, 267.
          Shirotani, M., et al. 1991. J. Pharmacol. Exp. Ther. 259, 738.
          Asano, T., et al. 1990. Eur. J. Pharmacol. 190, 365.
          Sasaki, Y., and Sasaki, Y. 1990. Biochem. Biophys. Res. Commun. 171, 1182.
          Asano, T., et al. 1989. Br. J. Pharmacol. 98, 1091.
          Product Information
          CAS number103745-39-7
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₁₄H₁₇N₃O₂S · 2HCl
          Chemical formulaC₁₄H₁₇N₃O₂S · 2HCl
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetPKA
          Primary Target IC<sub>50</sub>10.7 µM inhibiting Rho-associated kinase (ROCK)
          Primary Target K<sub>i</sub>.6 µM, 1.6 µM, 36 µM, inhibiting protein kinase A, protein kinase G, myosin light chain kinase, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          371970

          References

          Reference overview
          Watanabe, K., et al. 2007. Nature Biotech. 25, 681.
          Swärd, K., et al. 2000. J. Physiol. 522, 33.
          Takizawa, S., et al. 1993. Eur. J. Pharmacol. 250, 431.
          Seto, M., et al. 1991. Eur. J. Pharmacol. 195, 267.
          Shirotani, M., et al. 1991. J. Pharmacol. Exp. Ther. 259, 738.
          Asano, T., et al. 1990. Eur. J. Pharmacol. 190, 365.
          Sasaki, Y., and Sasaki, Y. 1990. Biochem. Biophys. Res. Commun. 171, 1182.
          Asano, T., et al. 1989. Br. J. Pharmacol. 98, 1091.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-January-2010 RFH
          SynonymsFasudil, (5-Isoquinolinesulfonyl)homopiperazine, 2HCl, PKG Inhibitor VII
          DescriptionA cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), and myosin light chain kinase (Ki = 3.6 µM). Also reported to potently inhibit Rho-associated kinase (ROCK; IC50 = 10.7 µM). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
          FormWhite solid
          CAS number103745-39-7
          Chemical formulaC₁₄H₁₇N₃O₂S · 2HCl
          Structure formula
          Purity≥98% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
          Toxicity Harmful
          ReferencesWatanabe, K., et al. 2007. Nature Biotech. 25, 681.
          Swärd, K., et al. 2000. J. Physiol. 522, 33.
          Takizawa, S., et al. 1993. Eur. J. Pharmacol. 250, 431.
          Seto, M., et al. 1991. Eur. J. Pharmacol. 195, 267.
          Shirotani, M., et al. 1991. J. Pharmacol. Exp. Ther. 259, 738.
          Asano, T., et al. 1990. Eur. J. Pharmacol. 190, 365.
          Sasaki, Y., and Sasaki, Y. 1990. Biochem. Biophys. Res. Commun. 171, 1182.
          Asano, T., et al. 1989. Br. J. Pharmacol. 98, 1091.

          Related Products & Applications

          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Rho Kinase (ROCK) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors