371955 | H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem

371955
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₇N₃O₂S · 2HCl 108930-17-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      371955-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA broad-based, cell-permeable, reversible, ATP-competitive serine/threonine kinase inhibitor. Inhibits protein kinase A (Ki = 3.0 µM), myosin light chain kinase (Ki = 97 µM), protein kinase C (Ki = 6.0 µM), and protein kinase G (Ki = 5.8 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.
          Catalogue Number371955
          Brand Family Calbiochem®
          Synonyms1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl
          References
          ReferencesKu, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
          Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
          Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1334.
          Gimond, C., et al. 1992. Exp. Cell Res. 203, 365.
          Quick, J., et al. 1992. Biochem. Biophys. Res. Commun. 187, 657.
          Bouli, N.M., and Davis, M. 1990. Brain Res. 525, 198.
          Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther. 255, 1218.
          Schachtele, C., et al. 1988. Biochem. Biophys. Res. Commun. 151, 542.
          Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun. 125, 258.
          Product Information
          CAS number108930-17-2
          ATP CompetitiveY
          FormLight yellow lyophilized solid
          Hill FormulaC₁₄H₁₇N₃O₂S · 2HCl
          Chemical formulaC₁₄H₁₇N₃O₂S · 2HCl
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMLCK
          Primary Target K<sub>i</sub>3.0 µM, 97 µM, 6.0 µM, 5.8 µM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          371955

          References

          Reference overview
          Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
          Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
          Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1334.
          Gimond, C., et al. 1992. Exp. Cell Res. 203, 365.
          Quick, J., et al. 1992. Biochem. Biophys. Res. Commun. 187, 657.
          Bouli, N.M., and Davis, M. 1990. Brain Res. 525, 198.
          Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther. 255, 1218.
          Schachtele, C., et al. 1988. Biochem. Biophys. Res. Commun. 151, 542.
          Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun. 125, 258.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          PKC Pathway Poster PDF ( 676 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-January-2010 RFH
          Synonyms1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl
          DescriptionA broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (Ki = 97 µM), protein kinase A (Ki = 3.0 µM), protein kinase C (Ki = 6 µM), and protein kinase G (Ki = 5.8 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.
          FormLight yellow lyophilized solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number108930-17-2
          Chemical formulaC₁₄H₁₇N₃O₂S · 2HCl
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityH₂O (20 mg/ml). Further dilute with aqueous buffers just prior to use.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
          Toxicity Standard Handling
          ReferencesKu, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
          Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
          Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1334.
          Gimond, C., et al. 1992. Exp. Cell Res. 203, 365.
          Quick, J., et al. 1992. Biochem. Biophys. Res. Commun. 187, 657.
          Bouli, N.M., and Davis, M. 1990. Brain Res. 525, 198.
          Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther. 255, 1218.
          Schachtele, C., et al. 1988. Biochem. Biophys. Res. Commun. 151, 542.
          Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun. 125, 258.

          Related Products & Applications

          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors