|Description||Guava® easyCyte 8HT Benchtop Flow Cytometer|
|Overview||The Guava® easyCyte 8HT Flow Cytometer offers absolute cell counts and eight parameters (6 fluorescent colors, 2 light scatter), from dual modulated blue and red lasers. Common assays include: immunophenotyping, cell signaling, cell health and compound screening. Its built-in 96-well autosampler enables reliable plate and tube sampling. The system runs FlowCellect & Guava Kits, plus user-defined reagents, using InCyte Software for data acquisition & analysis.
Learn More about this Flow Cytometer!
|Application||The guava easyCyte 8HT Benchtop Flow Cytometer offers absolute cell counts & high-demand features, such as eight parameters (6 fluorescent colors, 2 light scatter), from dual modulated blue & red lasers.|
|Cell Number per Assay||10 - 500 cells/µL|
|Sample Volume||125 µL|
|Throughput||12 uL/min to 60 uL/min|
|Height||10 in. (25.4 cm)|
|Width||20.3 in. (51.5 cm)|
|Depth||23.4 in. (59 cm)|
|Dimensions||10” (25.4 cm) h x 20.3” (51.5 cm) w x 23.4” (59 cm) d|
|Safety Information according to GHS|
|Storage and Shipping Information|
|Material Size||1 ea|
|Reference overview||Pub Med ID|
|Melatonin triggers p53(Ser) phosphorylation and prevents DNA damage accumulation. |
Santoro, R, et al.
Oncogene, (2011) 2011
Several epidemiological studies have shown that high levels of melatonin, an indolic hormone secreted mainly by the pineal gland, reduce the risks of developing cancer, thus suggesting that melatonin triggers the activation of tumor-suppressor pathways that lead to the prevention of malignant transformation. This paper illustrates that melatonin induces phosphorylation of p53 at Ser-15 inhibiting cell proliferation and preventing DNA damage accumulation of both normal and transformed cells. This activity requires p53 and promyelocytic leukemia (PML) expression and efficient phosphorylation of p53 at Ser-15 residue. Melatonin-induced p53 phosphorylation at Ser-15 residue does not require ataxia telangiectasia-mutated activity, whereas it is severely impaired upon chemical inhibition of p38 mitogen-activated protein kinase activity. By and large, these findings imply that the activation of the p53 tumor-suppressor pathway is a critical mediator of melatonin and its anticancer effects. Therefore, it provides molecular insights into increasing observational evidence for the role that melatonin has in cancer prevention.Oncogene advance online publication, 17 October 2011; doi:10.1038/onc.2011.469.
|Guava Platforms Datasheet|
|guava® easyCyte™ 8HT Flow Cytometry System|
|The Immunology of Cancer (EMD)|
Newsletters / Publications
|Cellutions - The Newsletter for Cell Biology Researchers Vol 1: 2012|
|Cellutions - The Newsletter for Cell Biology Researchers Vol 3:2012|
|Cellutions - The newsletter for Cell Biology Researchers Volume 3: 2011|
|Cellutions Newsletter: 2011, Vol. 2|